Evidence map›Paper›PMID 41144175›Full record

SynthesisClinical reviews in allergy & immunology2025

The Genomics/Genetics of Primary Biliary Cholangitis: The Case for a Functional SNP rs10893900 in ETS1/FLI1 and Review of the Literature.

Mingming Zhang, Chan Wang, Yexi Huang, Lu Wang, Yaping Dai, Yuzhang Jiang, Chongxu Han, Yuhua Gong, Li Li, Ye Tian and 11 more

Abstract readReviewMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Clinical reviews in allergy & immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Mingming Zhang *Key Laboratory of Developmental Genes and Human Diseases, School of Life Science and Technology, Southeast University, Nanjing, 210096, Jiangsu, China.
Chan Wang *Department of Laboratory Medicine, The Fourth Affiliated Hospital of Nanjing Medical University, Nanjing, 210031, Jiangsu, China.
Yexi HuangKey Laboratory of Developmental Genes and Human Diseases, School of Life Science and Technology, Southeast University, Nanjing, 210096, Jiangsu, China.
Lu WangKey Laboratory of Developmental Genes and Human Diseases, School of Life Science and Technology, Southeast University, Nanjing, 210096, Jiangsu, China.
Yaping DaiDepartment of Laboratory Medicine, The Fifth People's Hospital of Wuxi, Wuxi, Jiangsu, 214000, China.
Yuzhang JiangDepartment of Laboratory Medicine, Huai'an First People's Hospital, Nanjing Medical University, Huai'an, Jiangsu, 223300, China.
Chongxu HanDepartment of Laboratory Medicine, Clinical Medical College, Subei People's Hospital, Yangzhou University, Yangzhou, 225001, Jiangsu, China.
Yuhua GongDepartment of Laboratory Medicine, The Third People's Hospital of Zhenjiang, Zhenjiang, 212021, Jiangsu, China.
Li LiDepartment of Clinical Laboratory, ZhongDa Hospital, Southeast University, Nanjing, 210009, Jiangsu, China.
Ye TianDepartment of Radiology & Oncology, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, Jiangsu, China.
Wenyan TianDepartment of Gastroenterology, The First Affiliated Hospital of Soochow University, Suzhou, 215006, Jiangsu, China.
Runhao LinKey Laboratory of Developmental Genes and Human Diseases, School of Life Science and Technology, Southeast University, Nanjing, 210096, Jiangsu, China.
Shuna TongKey Laboratory of Developmental Genes and Human Diseases, School of Life Science and Technology, Southeast University, Nanjing, 210096, Jiangsu, China.
Meilin WangDepartment of Genetic Toxicology, The Key Laboratory of Modern Toxicology of Ministry of Education, Center for Global Health, Nanjing Medical University School of Public Health, Nanjing, 210029, Jiangsu, China.
Xiong MaDepartment of Gastroenterology and Hepatology, Shanghai Institute of Digestive Diseases, Shanghai Jiao Tong University School of Medicine Affiliated Renji Hospital, Shanghai, 200001, China.
Fang QiuDepartment of Laboratory Medicine, The Fourth Affiliated Hospital of Nanjing Medical University, Nanjing, 210031, Jiangsu, China.
Zhexiong LianGuangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510080, Guangdong, China.
M Eric GershwinDivision of Rheumatology, Allergy and Clinical Immunology, University of California at Davis, Davis, CA, 95616, USA.
Xingjuan ShiKey Laboratory of Developmental Genes and Human Diseases, School of Life Science and Technology, Southeast University, Nanjing, 210096, Jiangsu, China. xingjuanshi@seu.edu.cn.
Weichang ChenDepartment of Gastroenterology, The First Affiliated Hospital of Soochow University, Suzhou, 215006, Jiangsu, China. weichangchen@126.com.
Xiangdong LiuKey Laboratory of Developmental Genes and Human Diseases, School of Life Science and Technology, Southeast University, Nanjing, 210096, Jiangsu, China. xiangdongliu@seu.edu.cn.

Funding

National Natural Science Foundation of China 81870397National Natural Science Foundation of China 82170370National Natural Science Foundation of China 82370530Shenzhen Kangzhe Pharmaceutical Co. Ltd URC-126/PBC
6 · The paper itself

Abstract

ETS1 and FLI1 exhibit distinct roles in immunoregulation and autoimmune pathogenesis. Previous transethnic genome-wide meta-analyses incorporating our Han Chinese population established significant associations between ETS1 single-nucleotide polymorphisms (SNPs) and susceptibility to primary biliary cholangitis (PBC). In our earlier genome-wide association study (GWAS), ten SNPs within the ETS1 and FLI1 loci demonstrated modest yet suggestive associations with PBC susceptibility in the Han Chinese population. To validate these putative risk loci, we conducted an independent replication study of rs10893900 and rs2246290 using a separate Han Chinese PBC cohort. A meta-analysis combining data from two stages identified rs10893900 as a genome-wide significant variant (P = 4.55 × 10

Indexed as

Liver Cirrhosis, BiliaryPolymorphism, Single NucleotideProto-Oncogene Protein c-ets-1Genetic Predisposition to DiseaseGenome-Wide Association StudyGenomicsHumansETS1 protein, humanProto-Oncogene Protein c-ets-1E26 transformation specific-1Friend leukemia integration 1Han ChinesePrimary biliary cholangitisSingle-nucleotide polymorphism

Identifiers

PMID41144175

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.