ArticlePloS one2025
Survival outcomes and prognostic factors in children and adults with medulloblastoma from a Latin America country: A retrospective cohort.
Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFew studies have evaluated the real-world outcomes of patients with medulloblastoma with contradictory results. Therefore, we aimed to compare the characteristics, survival outcomes, and prognostic factors between children and adults with medulloblastoma.
methodsWe conducted a retrospective cohort study in a single academic center between 2000 and 2016. Patients were categorized into children and adolescents (≤19 years) and adults (>19 years). Overall survival (OS) and disease-free survival (DFS) were estimated with the Kaplan-Meier method. Prognostic factors were determined using Cox models.
resultsIn total, 173 patients were included (79 adults and 94 children). No differences were observed in clinical characteristics according to age groups. At 5 years, DFS was 36.88% in children and 50.99% in adults (p = 0.476). Prognostic factors of DFS in adults were radiotherapy (adjusted Hazard ratio [aHR]: 0.22; 95% confidence interval [CI]: 0.07-0.67) and performance status 2-4 (aHR: 3.60; 95% CI: 1.48-8.77); while in children was radiotherapy (aHR: 0.33; 95% CI: 0.11-0.96) and chemotherapy (aHR: 0.34; 95% CI: 0.14-0.84). The 5-year OS rate was 64.25% in children and 60.87% in adults (p = 0.447). In adults, prognostic factors of OS were histologic type (aHR: 6.11, 95% CI: 1.19-31.48, for anaplastic) and radiotherapy (aHR: 0.22, 95% CI: 0.07-0.71), while in children and adolescents, lower performance status (aHR: 2.43, 95% CI: 1.09-5.39, for performance status 2-4) was the only prognostic factor. Subgroup analyses revealed a trend toward improved DFS and significantly better OS among adults who completed chemotherapy, highlighting the importance of treatment adherence.
conclusionsBoth populations demonstrated similar survival rates that were comparable to or lower than those reported in previous studies. In adults, performance status and radiotherapy were prognostic factors for DFS, while histologic type and radiotherapy for OS. In children, chemotherapy and radiotherapy were prognostic factors for DFS, and performance status was the only OS prognostic factor. These findings underscore the importance of optimizing treatment adherence and completing standard therapies, as well as improving staging practices, to enhance outcomes in real-world settings.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.