Neuroprotection and Axonal Regeneration via ECM-Mimetic Nanofibers Incorporating Metal-Phenolic Network Nanoparticles Toward Spinal Cord Injury Repair.

Shu Chen, Bixue Wang, Qiya Zhang, Changsheng Liu, Xi Chen

Abstract read

In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it

0cells of the map it votes in

5citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

Smart-responsive electrospun scaffolds (SRES) for neural repair: Recent advances and future prospects.Bioactive materials · 2026
Review
Tissue engineering for traumatic spinal cord injury: Research advances and clinical translation.Bioactive materials · 2026
Review
The Complex Interplay in Quantum Dot Neurotoxicity: From Environmental Exposure to Disruption of Neural Homeostasis.Toxics · 2026
Review
Nanotube-Assisted Motor Neuron and Neuromuscular Junction Stabilization in Spinal Muscular Atrophy: A Hypothesis for Adjunctive Therapy.Neurology international · 2026
Review
Neuroprotection and Axonal Regeneration via ECM-Mimetic Nanofibers Incorporating Metal-Phenolic Network Nanoparticles Toward Spinal Cord Injury Repair.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Shu ChenKey Laboratory for Ultrafine Materials of Ministry of Education, Frontiers Science Center for Materiobiology and Dynamic Chemistry, Engineering Research Center of Biomedical Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai, 200237, China.ORCID https://orcid.org/0009-0002-9174-6432

Bixue WangKey Laboratory for Ultrafine Materials of Ministry of Education, Frontiers Science Center for Materiobiology and Dynamic Chemistry, Engineering Research Center of Biomedical Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai, 200237, China.

Qiya ZhangKey Laboratory for Ultrafine Materials of Ministry of Education, Frontiers Science Center for Materiobiology and Dynamic Chemistry, Engineering Research Center of Biomedical Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai, 200237, China.

Changsheng LiuKey Laboratory for Ultrafine Materials of Ministry of Education, Frontiers Science Center for Materiobiology and Dynamic Chemistry, Engineering Research Center of Biomedical Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai, 200237, China.ORCID https://orcid.org/0000-0003-0509-7334

Xi ChenKey Laboratory for Ultrafine Materials of Ministry of Education, Frontiers Science Center for Materiobiology and Dynamic Chemistry, Engineering Research Center of Biomedical Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai, 200237, China.ORCID https://orcid.org/0000-0002-3925-3684

Funding

Basic Science Center Project of National Natural Science Foundation of China T2288102National Key R&D Plan Project of China 2022YFC2403200National Natural Science Foundation of China 32371464

6 · The paper itself

Abstract

Spinal cord injury (SCI) triggers secondary pathological cascades, such as excitotoxicity, neuroinflammation, and glial scarring, creating a hostile injury microenvironment that exacerbates the death of spared neurons and inhibits axonal regeneration, thus impeding functional recovery. While aligned electrospun nanofibers (NFs) fabricated from decellularized extracellular matrix (dECM) can mimic topological and bioactive cues of native ECM to guide axonal regrowth, they fail to intervene in these secondary pathological cascades. To address this limitation, Mg

Indexed as

AxonsExtracellular MatrixNanofibersNanoparticlesNerve RegenerationNeuroprotectionSpinal Cord InjuriesAnimalsCatechinDisease Models, AnimalMiceNeuroprotective AgentsTissue ScaffoldsCatechinepigallocatechin gallateNeuroprotective Agentsaxonal regenerationdecellularized extracellular matrixmetal–phenolic networksneuroprotectionspinal cord injury

Identifiers

PMID41144843

DOI10.1002/advs.202513825

PMCPMC12767005

What Socratic holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.