ArticleCell death discovery2025
M2 polarization of macrophage protects the lung cancer cells from cold atmospheric plasma via alleviating endoplasmic reticulum stress.
Article in Cell death discovery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A dual-index framework for cold atmospheric plasma dosing: A meta-analysis of parametric control from volumetric redox flux to redox homeostatic status.Redox biology · 2026Pooled it
- Dual-transferred atmospheric-pressure plasma jet modulates matrix metalloproteinase expression in breast cancer stem cells.Biochemistry and biophysics reports · 2026Article
- A new mouse model of biomass smoke-related chronic obstructive pulmonary disease combining porcine pancreatic elastase nebulization.Journal of thoracic disease · 2025Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Although cold atmospheric plasma (CAP) has been proved to kill various kinds of tumor cells effectively, most previous studies were performed on the in vitro tumor cell model in the absence of tumor microenvironment (TME), resulting in limited insights to its clinical application. Here, we explored the anti-tumor effect of CAP based on a co-culture model of macrophages and lung cancer cells, and it was found that CAP could induce M2 polarization of macrophages and then release IL-10. The released IL-10 activated the STAT1/STAT3 signaling pathway to alleviate CAP-induced endoplasmic reticulum stress in tumor cells, finally resulting in attenuation of programmed death of tumor cells after CAP exposure. In particular, the presence of macrophages caused the reduction of GSDME-dependent pyroptosis, which was proved to play an important role in activation of anti-tumor immunity, induced by CAP. Our findings provide evidences to a better understanding of the anti-tumor effect of CAP and insights to promote the clinical application of CAP tumor therapy.
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.