Trial reportNutrition & diabetes2025
Does partial replacement of animal protein with plant protein in the diet affect components of metabolic syndrome, adropin levels, and the atherogenic index of plasma? Results from a parallel randomized clinical trial in adults with metabolic syndrome.
Trial report in Nutrition & diabetes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundFew studies evaluated the effect of different proportions of dietary plant- and animal-based protein on metabolic syndrome (MetS) and its related biomarkers.
objectiveConsidering the effect of various types of dietary sources of protein on metabolic health and inconsistent results, this study sought to examine the impact of partially substituting animal protein with plant protein in the diet on the components of MetS, atherogenic index of plasma, and serum adropin values.
methodsIn this parallel, randomized clinical trial with two arms, 73 participants with MetS were randomly allocated to one of two slightly calorie-restricted intervention diets with different proportions of protein sources, including a plant-based protein diet (70% plant-based protein and 30% animal-based protein) and an animal-based protein diet (30% plant-based protein and 70% animal-based protein) for 10 weeks. All analyses were performed based on both intention-to-treat and per-protocol principles.
resultsMean age in the plant and animal-based protein groups was 44.0 ± 9.8 and 43.9 ± 9.8 years, respectively. Within each group, weight, body mass index, systolic and diastolic blood pressure, and atherogenic index of plasma significantly decreased, and adropin levels significantly increased after the intervention (P < 0.05). However, waist circumference (WC) and triglyceride (TG) levels showed a significant decrease only in the plant protein group, and high-density lipoprotein cholesterol (HDL-c) levels illustrated a significant increase only in the animal protein group (P < 0.05). Between-group differences in both crude and adjusted models did not show any significant changes between the two intervention arms (P > 0.05). However, findings of per-protocol analyses illustrated a significant difference only in mean adropin values in two study arms.
conclusionOur findings revealed that both diets based on plant and animal protein were associated with improved in anthropometric indices, MetS components, atherogenic index of plasma, and elevated serum adropin levels. Nevertheless, no statistically significant difference was identified between the two groups.
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