ArticleScientific reports2025
Triglyceride-glucose index variability and risk of all-cause and cardiovascular mortality.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
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Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Stress hyperglycemia ratio in coronary artery disease: a systematic review and meta-analysis of severity and prognosis.Cardiovascular diabetology · 2026Pooled it
- Association between the triglyceride-glucose index and major adverse cardiovascular and cerebrovascular events after percutaneous coronary intervention.Journal of thoracic disease · 2026Article
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3 authors.
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Abstract
Triglyceride-glucose (TyG) index is a reliable marker of insulin resistance with predictive value for cardiovascular risk. While metabolic variability independently impacts cardiovascular outcomes and mortality, the clinical significance of TyG index variability remains unclear. We investigated whether higher TyG index variability increases the risk of mortality. This retrospective cohort study analyzed data from 3,094,062 individuals who participated in the National Health Screening Program from 2009 to 2014. TyG index variability independent of the mean (VIM) was calculated and participants were categorized into quartiles. Cox proportional hazards regression analysis was used to estimate hazard ratio (HR) with 95% confidence interval (CI) for all-cause and cardiovascular mortality. Over a median follow-up of 9.1 years, a total of 137,339 (4.44%) deaths were recorded, including 15,261 (0.56%) from cardiovascular causes. Mortality rose stepwise across TyG index VIM quartiles. Compared to Quartile 1, Quartile 4 had the highest risk of all-cause mortality (HR 1.18, 95% CI 1.16-1.21, P < 0.001) and cardiovascular mortality (HR 1.13, 95% CI 1.06-1.21, P < 0.001). Higher TyG index variability is associated with increased all-cause and cardiovascular mortality. Serial monitoring of changes in TyG index may contribute to reducing mortality risk through early detection and intervention.
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