Evidence map›Paper›PMID 41145720›Full record

ArticleScientific reports2025

Comparison of inflammatory cells, C-reactive protein, and lipid profile in atherosclerotic cardiovascular disease patients and healthy controls in Northwest Ethiopia.

Minyahl Kassye Mengstu, Getu Girmay, Kassaye Demeke Altaye, Wossen Habtu, Yoseph Tolcha, Emiyamrew Getnet, Mulualem Lemma, Wubet Birhan

Abstract readComparative Study
PubMed Full text at PMC Publisher
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Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Minyahl Kassye MengstuDepartment of Medical Laboratory Sciences, College of Medicine and Health Sciences, Arba Minch University, Arba Minch, Ethiopia. minyahlkassye@gmail.com.
Getu GirmayDepartment of Immunology and Molecular Biology, School of Biomedical and Laboratory Science, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia. getugirmay2008@yahoo.com.
Kassaye Demeke AltayeDepartment of Emergency and Critical Care Medicine, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
Wossen HabtuDepartment of Clinical Chemistry, Ethiopian Public Health Institute, Addis Ababa, Ethiopia.
Yoseph TolchaDepartment of Clinical Chemistry, Ethiopian Public Health Institute, Addis Ababa, Ethiopia.
Emiyamrew GetnetDepartment of Medical Laboratory Sciences, College of Medicine and Health Sciences, Wollo University, Dessie, Ethiopia.
Mulualem LemmaDepartment of Immunology and Molecular Biology, School of Biomedical and Laboratory Science, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
Wubet BirhanDepartment of Immunology and Molecular Biology, School of Biomedical and Laboratory Science, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Atherosclerotic cardiovascular disease (ASCVD) remains a leading cause of global mortality and disability. Inflammation is increasingly recognized as a key driver in the pathogenesis of ASCVD. However, data on the specific distribution of inflammatory cells, high-sensitivity C-reactive protein (hsCRP), and lipid profiles among ASCVD patients in this region remain limited. Therefore, we aimed to assess the distribution of inflammatory cells, hsCRP, and lipid profile among ASCVD patients and healthy controls. A comparative cross-sectional study was conducted from June to November 2024 at the University of Gondar Comprehensive Specialized Hospital, recruiting 101 ASCVD patients and 101 healthy controls using simple random sampling. Sociodemographic, behavioral, and clinical data were collected using a structured questionnaire, measurement, and chart review. Six milliliters of fasting venous blood were drawn for complete blood count (CBC), hsCRP, and lipid profile analyses. Data were analyzed using STATA version 14. Means were compared using independent t-tests and ANOVA at a significance level of p ≤ 0.05 with a 95% confidence interval. Of the 202 study participants, 101 were ASCVD patients and 101 were healthy controls. The mean ages were 57.42 ± 12.88 years for ASCVD patients and 56.30 ± 10.93 years for healthy controls. ASCVD patients had higher mean WBC and neutrophil counts, and higher median monocytes, NLR, MLR, hsCRP, TC, and LDL (p ≤ 0.05) than controls, while median eosinophil levels were significantly lower (p ≤ 0.05). Our study showed that ASCVD patients had higher inflammatory cell counts, ratios (NLR, MLR), hsCRP, total cholesterol, and LDL than controls, highlighting the potential roles of inflammation and dyslipidemia in ASCVD development.

Indexed as

AtherosclerosisC-Reactive ProteinLipidsAdultAgedCase-Control StudiesCross-Sectional StudiesEthiopiaFemaleHumansInflammationMaleMiddle AgedC-Reactive ProteinLipidsAtherosclerotic cardiovascular diseaseC-reactive proteinInflammatory cellsInflammatory cells ratioLipid profileNorthwest ethiopiaSystemic inflammation

Identifiers

PMID41145720
PMCPMC12559173

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.