ArticleCardiovascular and interventional radiology2025
Intravenous Thrombolysis Prior to Endovascular Treatment in Basilar Artery Occlusions: A Patient Pooled Analysis of Four Randomized Controlled Trials.
Article in Cardiovascular and interventional radiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Bridging therapy versus mechanical thrombectomy alone in patients with basilar artery occlusion and mild symptoms: a retrospective observational study.Journal of neurology · 2026Observational
- Invited Commentary to: Single-Branched Stent-Graft for Thoracic Aortic Diseases Involving Left Subclavian Artery.Cardiovascular and interventional radiology · 2025Article
Corrections and comments
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Authors and funding
21 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThis study assessed intravenous thrombolysis (IVT) prior to endovascular treatment (EVT) versus EVT alone in patients with basilar artery occlusions (BAO).
methodsThis patient-level pooled analysis included data from four randomized controlled trials within the VERITAS collaboration (BEST, BASICS, ATTENTION, and BAOCHE). Patients were stratified into IVT plus EVT and EVT alone. Primary outcome was favorable functional outcome, defined as modified Rankin Scale (mRS) score of 0-3 at 3 months. Secondary outcomes included good functional outcome (mRS 0-2), mortality, and symptomatic intracranial hemorrhage (sICH) rates. Regression analyses were adjusted for covariates identified from baseline differences and univariable analyses. Inverse probability of treatment weighting (IPTW) and propensity score matching (PSM) to balance baseline differences and subgroup analyses were also conducted.
resultsOut of total 988 included patients, 556 patients were allocated for EVT and analyzed. No significant differences were observed between patients treated with or without IVT prior to EVT in terms of mRS 0-3 at 3 months (47 vs 44%, adjusted odds ratio [aOR]:0.88, 95%CI 0.57-1.36), mRS 0-2 (39 vs 32%, aOR:1.22, 95%CI 0.78-1.91), mortality (33 vs 38%, aOR:0.93, 95%CI 0.59-1.44), and sICH rates (6.3 vs 4.9%, aOR:1.87, 95%CI 0.77-4.57). IPTW and PSM analyses yielded consistent results. Subgroup analyses did not reveal any differential treatment effect including time from symptom onset to imaging.
conclusionsFindings from this patient-level pooled analysis of four randomized controlled trials suggest that bridging IVT over EVT alone was safe but not associated with significant improved outcomes. LEVEL OF EVIDENCE 2B: Level 2b, cohort study of a patient-level meta-analysis of 4 RCT's.
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