Evidence map›Paper›PMID 41145946›Full record

ArticleReproductive sciences (Thousand Oaks, Calif.)2025

Perillaldehyde Attenuates Insulin Resistance and High Glucose-Induced Ferroptosis in Trophoblast Cells via Regulation of PTPN1/Akt/Foxo1 Signaling Pathway.

Xing Wang, Yu Lu, Suyu Wang, Xueqin Wang, Shufang Yang, Chengyuan Zhao

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Article in Reproductive sciences (Thousand Oaks, Calif.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

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No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xing Wang *Department of Endocrinology, Affiliated Hospital 2 of Nantong University and First People's Hospital of Nantong City, Nantong, China.
Yu Lu *Department of Endocrinology, The Affiliated Taizhou People's Hospital of Nanjing Medical University, Taizhou School of Clinical Medicine, Nanjing Medical University, No. 366 Taihu Road Hailing District, Taizhou, 225300, Jiangsu Province, China.
Suyu WangDepartment of Endocrinology, The First Hospital of Nanjing Medical University, Nanjing, China.
Xueqin WangDepartment of Endocrinology, Affiliated Hospital 2 of Nantong University and First People's Hospital of Nantong City, Nantong, China.
Shufang YangDepartment of Endocrinology, The Affiliated Taizhou People's Hospital of Nanjing Medical University, Taizhou School of Clinical Medicine, Nanjing Medical University, No. 366 Taihu Road Hailing District, Taizhou, 225300, Jiangsu Province, China.
Chengyuan ZhaoDepartment of Endocrinology, The Affiliated Taizhou People's Hospital of Nanjing Medical University, Taizhou School of Clinical Medicine, Nanjing Medical University, No. 366 Taihu Road Hailing District, Taizhou, 225300, Jiangsu Province, China. Zhaochengyuan123@163.com.ORCID 0009-0004-0938-1468

Funding

Innovative Research Group Project of the National Natural Science Foundation of China 81900664Scientific Research Project of Health Commission in Jiangsu Province LGY2020067Scientific Research Project, Taizhou School of Clinical Medicine, Nanjing Medical University TZKY20220110Six Talent Peaks Project in Jiangsu Province WSN-336
6 · The paper itself

Abstract

Ferroptosis and insulin resistance (IR) play crucial roles in the development of gestational diabetes mellitus (GDM). This study aims to analyze the effects of perillaldehyde (PAE) on ferroptosis and IR in human trophoblast cells, as well as its underlying mechanism in these effects. In this study, human trophoblasts (HTR-8/SVneo cells) treated with high glucose or in combination with insulin were used as in vitro models of GDM. The protective effects of PAE were evaluated by detecting insulin resistance and ferroptosis. GSE datasets (GSE154414 and GSE54157), SwissTargetPrediction, and GeneCards were used for gene target prediction. Results showed that PAE mitigated the decrease in HTR-8/SVneo cell viability caused by HG treatment. PAE exerted a protective effect against HG-triggered ferroptosis in HTR-8/SVneo cells by reducing ROS, Fe

Indexed as

FerroptosisForkhead Box Protein O1GlucoseInsulin ResistanceProtein Tyrosine Phosphatase, Non-Receptor Type 1Proto-Oncogene Proteins c-aktTrophoblastsCell LineDiabetes, GestationalFemaleHumansPregnancySignal TransductionForkhead Box Protein O1FOXO1 protein, humanGlucoseProtein Tyrosine Phosphatase, Non-Receptor Type 1Proto-Oncogene Proteins c-aktPTPN1 protein, humanFerroptosisGestational diabetes mellitusInsulin resistancePerillaldehydePTPN1/Akt/Foxo1 signaling pathway

Identifiers

PMID41145946

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.