Evidence map›Paper›PMID 41146138›Full record

SynthesisJournal of translational medicine2025

Implementation of precision medicine in treating non-communicable diseases: a systematic review.

Shuang Liang, Elizabeth Kennedy, Nyree Gale, Paul Watson, Mahitha Ramanathan, Arya Shinde, Skye McKay, Andrea Torres-Robles, Zhicheng Li, Jeffery Chan and 13 more

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of translational medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Shuang Liang *Implementation to Impact, School of Population Health, Faculty of Medicine and Health, UNSW Sydney, Sydney, NSW, Australia. shuang.liang4@unsw.edu.au.ORCID 0000-0002-3865-8655
Elizabeth Kennedy *Implementation to Impact, School of Population Health, Faculty of Medicine and Health, UNSW Sydney, Sydney, NSW, Australia.
Nyree GaleImplementation to Impact, School of Population Health, Faculty of Medicine and Health, UNSW Sydney, Sydney, NSW, Australia.
Paul WatsonImplementation to Impact, School of Population Health, Faculty of Medicine and Health, UNSW Sydney, Sydney, NSW, Australia.
Mahitha RamanathanImplementation to Impact, School of Population Health, Faculty of Medicine and Health, UNSW Sydney, Sydney, NSW, Australia.
Arya ShindeImplementation to Impact, School of Population Health, Faculty of Medicine and Health, UNSW Sydney, Sydney, NSW, Australia.
Skye McKayImplementation to Impact, School of Population Health, Faculty of Medicine and Health, UNSW Sydney, Sydney, NSW, Australia.
Andrea Torres-RoblesImplementation to Impact, School of Population Health, Faculty of Medicine and Health, UNSW Sydney, Sydney, NSW, Australia.
Zhicheng LiImplementation to Impact, School of Population Health, Faculty of Medicine and Health, UNSW Sydney, Sydney, NSW, Australia.
Jeffery ChanImplementation to Impact, School of Population Health, Faculty of Medicine and Health, UNSW Sydney, Sydney, NSW, Australia.
Helen JonesAcademic Engagement, Faculty of Medicine and Health, UNSW Sydney, Sydney, NSW, Australia.
Mandy L BallingerPrecision Care Initiative, UNSW Sydney, Sydney, NSW, Australia.
Phyllis ButowPrecision Care Initiative, UNSW Sydney, Sydney, NSW, Australia.
David GoldsteinPrecision Care Initiative, UNSW Sydney, Sydney, NSW, Australia.
Kathryn LeaneyPrecision Care Initiative, UNSW Sydney, Sydney, NSW, Australia.
Sandy MiddletonPrecision Care Initiative, UNSW Sydney, Sydney, NSW, Australia.
April MorrowImplementation to Impact, School of Population Health, Faculty of Medicine and Health, UNSW Sydney, Sydney, NSW, Australia.
David M ThomasPrecision Care Initiative, UNSW Sydney, Sydney, NSW, Australia.
Kathy M TuckerPrecision Care Initiative, UNSW Sydney, Sydney, NSW, Australia.
Milita ZaheedPrecision Care Initiative, UNSW Sydney, Sydney, NSW, Australia.
Bonny ParkinsonPrecision Care Initiative, UNSW Sydney, Sydney, NSW, Australia.
Frank LinPrecision Care Initiative, UNSW Sydney, Sydney, NSW, Australia.
Natalie TaylorImplementation to Impact, School of Population Health, Faculty of Medicine and Health, UNSW Sydney, Sydney, NSW, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNon-communicable diseases (NCDs) are a major global health and economic burden. Precision medicine has merged as a promising approach for treating NCDs by tailoring health interventions to individual profiles. Despite rapid advances, its effective implementation remains slow. This systematic review aimed to examine the implementation landscape for delivering precision medicine interventions, services, or programs for NCDs, focusing on barriers, facilitators, strategies, and outcomes.

methodsComprehensive searches were performed in PubMed, Embase, CINAHL, and Web of Science until November 2024. The search strategy comprised of four key concepts, i.e. precision medicine, NCDs, implementation, and public health. Articles published from 2014 onwards were included. Extracted data included study characteristics, populations, precision medicine intervention details, and information related to implementation. Relevant data were coded to implementation science frameworks and taxonomies. These included the updated Consolidated Framework for Implementation Research (CFIR 2.0), Expert Recommendations for Implementing Change (ERIC), and Proctor's outcomes framework. The QuADs tool was used to assess the risk of bias of included studies.

resultsA total of 10,039 records were identified, with 8,684 abstracts and 463 full texts screened. Of these, 68 studies met the inclusion criteria. While 64 studies reported implementation determinants [i.e. barriers (n = 61) and/or facilitators (n = 40)], approximately two-thirds proposed or implemented strategies that were primarily based on intuition. Key barriers identified included 'access to knowledge and information' (n = 34) and 'work infrastructure' (n = 21) within the Inner Setting, and 'financing' (n = 20) within the Outer Setting. While financial burdens were clearly attributed to patients and healthcare settings, there was less clarity and strategic direction regarding potential funding sources to support implementation strategies. Implementation Outcomes were reported in 46 instances, with Adoption being the most frequent. Service Outcomes, particularly Effectiveness, were generally positive, as were patient outcomes, primarily, mortality and morbidity.

conclusionDespite growing interest in precision medicine for treating NCDs, implementation evidence remains theoretically fragmented, making it difficult to identify implementation success patterns. Future efforts adopting targeted strategies and robust outcome evaluation, guided by implementation science, are needed to support effective integration of precision medicine into routine healthcare.

Indexed as

Noncommunicable DiseasesPrecision MedicineHumansImplementation ScienceHealth systemsImplementation scienceNon-communicable diseasesPrecision medicinePublic health

Identifiers

PMID41146138
PMCPMC12557925

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.