ReviewGut microbes2025
From bugs to behavior: targeting the gut-brain interface for addiction therapeutics.
Review in Gut microbes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Gut Microbiota in Addiction Biology: A Systematic Review of Substance-Induced Dysbiosis and Gut-Brain Axis Alterations.Medical sciences (Basel, Switzerland) · 2026Pooled it
- Metabolomic and gut microbial biomarkers of smoking cessation treatment in long-term drug therapy: a study protocol for a randomized controlled trial.Frontiers in psychiatry · 2026Article
- Neural mechanisms of food preference and reward processing: a review of multifaceted influencing factors and intervention strategies.Frontiers in nutrition · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Substance use disorders involving alcohol, cocaine, tobacco, opioids, and methamphetamine represent a significant global health burden, driven by the dysregulation of neurobiological and metabolic pathways in addiction. Emerging research highlights the gut-brain axis (GBA) as a critical mediator of addictive behaviors, with gut microbiota and their metabolites influencing bidirectional communication between the gastrointestinal tract and the central nervous system. This review synthesizes current evidence on how gut microbial communities modulate the brain's reward circuitry and the metabolism of addictive substances, thereby shaping behavioral and physiological responses to substance use. We explore the mechanistic interplay between microbial-derived metabolites (
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.