Trial reportDrug design, development and therapy2025
Effects of Oliceridine Versus Sufentanil on Hemodynamic Stability in Elderly Hypertensive Patients During Laryngeal Mask Airway Anesthesia: A Randomized Controlled Trial.
Trial report in Drug design, development and therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07713134 (Efficacy and Safety of the Biased μ-Opioid Receptor Agonist Oliceridine in Hysteroscopic Procedures), which is not on this map. Cited by 8 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Efficacy and Safety of the Biased μ-Opioid Receptor Agonist Oliceridine in Hysteroscopic Procedures
Who cites it
8 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Efficacy and safety of oliceridine versus sufentanil in perioperative anesthesia and analgesia: a systematic review and meta-analysis with trial sequential analysis.European journal of clinical pharmacology · 2026Pooled it
- Oliceridine versus sufentanil: a systematic review and meta-analysis of postoperative nausea and vomiting.BMC anesthesiology · 2026Pooled it
- Comparison of hemodynamic responses to endotracheal intubation with oliceridine and sufentanil during induction: a randomized controlled trial.BMC anesthesiology · 2026Trial
- Determination of the 90% effective dose of propofol combined with oliceridine or fentanyl for inhibiting the insertion response in upper gastrointestinal endoscopy: a dose-finding trial.Frontiers in medicine · 2026Trial
- Comparison of Oliceridine and Hydromorphone for Postoperative Analgesia in Adults Undergoing Lower Limb Fracture Surgery: A Randomized Controlled Non-Inferiority Trial.Drug design, development and therapy · 2026Trial
- Effect of Propofol Combined with Oliceridine versus Fentanyl on Desaturation During Gastrointestinal Endoscopy: A Randomized Clinical Trial.Drug design, development and therapy · 2026Trial
- Comparison of Postoperative Analgesic Efficacy of Oliceridine and Sufentanil in Total Laparoscopy Hysterectomy, a Clinical Double-Blind Controlled Trial.Drug design, development and therapy · 2026Trial
- Autonomic nervous system modulation by G protein-biased mu-opioid receptor agonists: A translational scoping review protocol.PloS one · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: To evaluate the efficacy and safety of low-dose oliceridine versus sufentanil in maintaining hemodynamic stability during laryngeal mask airway (LMA) general anesthesia in elderly hypertensive patients. Patients and Methods: A prospective, double-blind, randomized controlled trial was conducted with 80 elderly hypertensive patients (aged ≥65 years, SBP ≥140 mmHg and/or DBP ≥90 mmHg). Participants were randomized into two groups: the oliceridine group (Group O, n = 40) and the sufentanil group (Group S, n = 40). Hemodynamic parameters (SBP, DBP, MAP, HR) were recorded at baseline, after drug administration, and post-LMA placement. Adverse events (eg, hypotension, hypertension, nausea/vomiting) were analyzed using Chi-square or Fisher's exact tests. Results: Compared with sufentanil, oliceridine significantly reduced the hemodynamic fluctuations after laryngeal mask insertion. Specifically, the variability of mean arterial pressure (MAP) decreased ((ΔMAP: -4.8 ± 3.4 mmHg vs -15.7 ± 10.5 mmHg, mean difference: 10.9mmHg, 95% CI: 7.4 to 14.3 mmHg, P = 0.000). Although there was no significant difference in intubation response rate between the two drugs (7.5% vs 10.0%, Conclusion: Oliceridine may offer a safer alternative for hemodynamically fragile elderly patients during LMA anesthesia.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.