ArticleActa dermato-venereologica2025
Application of T-SPOT.TB in the Diagnosis of Cutaneous Myco-bacterium marinum Infections and Evaluation of Treatment Efficacy.
Article in Acta dermato-venereologica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study evaluated the diagnostic value and therapeutic efficacy assessment potential of the interferon-γ release assay T-SPOT.TB in cutaneous Mycobacterium marinum infections. A total of 145 patients diagnosed at the Institute of Dermatology, Chinese Academy of Medical Sciences (2020-2024), excluding tuberculosis cases, were retrospectively analysed. Clinical data including demographics, underlying diseases, pathology, microbiological culture, molecular identification, T-SPOT.TB results, treatment regimens, and outcomes were collected. T-SPOT.TB results before treatment, and at 3 and 6 months post-treatment, were compared to assess its diagnostic and monitoring utility. The baseline T-SPOT.TB positivity rate was 71% (95% CI: 63.2-77.8%). Among 17 patients retested at 3 months, positivity was 64.7% (p = 0.125), with median spot-forming cells (SFCs) significantly decreasing from 20.0 (IQR 8.5-41.0) to 8.0 (IQR 2.5-28.0) (p = 0.0007). Among 27 patients retested at 6 months, positivity was 59.3% (p = 0.344), with median SFCs decreasing from 12.0 (IQR 5.0-30.0) to 8.0 (IQR 3.0-13.0) (p = 0.0006). No significant difference in positivity rates was observed between 3 and 6 months post-treatment. The T-SPOT.TB assay shows significant diagnostic value for cutaneous M. marinum infections and facilitates early diagnosis. Declining SFC counts post-treatment provide useful reference for evaluating therapeutic response.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.