ArticlePest management science2026
Comparative lipidomic and proteomic analysis reveals species-specific differences in midgut composition and insecticide absorption between Apis mellifera and Bombus terrestris.
Article in Pest management science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe importance of bee pollinators for agricultural and ecological reasons is widely recognised and the declines in pollinator populations have been partly attributed to insecticide exposure in addition to habitat loss, climate change, pathogens and parasites. While metabolic detoxification of insecticides in bees is well-studied, less is known about species-specific differences in absorption. This study investigates the link between midgut composition and patterns of absorption in two key pollinator species, the Western honeybee Apis mellifera and the buff-tailed bumblebee Bombus terrestris.
resultsComprehensive lipidomic and proteomic analysis revealed large-scale differences in the gut composition between the two species, with B. terrestris showing a higher ratio of sphingomyelins to phosphatidylcholines compared to A. mellifera. Ex vivo Ussing chamber experiments and in vivo feeding assays demonstrated that the A. mellifera displayed higher midgut permeability for the two insecticides imidacloprid and chlorantraniliprole when compared to B. terrestris. The observed structural variation in midgut composition correlates with the differing absorption rates, suggesting a potential mechanism for species-specific variations in insecticide toxicity.
conclusionThe finding that A. mellifera midguts display a higher rate of insecticidal absorption provides a novel insight into the role of absorption in bee toxicology. This also has implications for the development of more selective insecticides and improved risk assessment strategies for non-target organisms. © 2025 The Author(s). Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.