In one paragraphArticle in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
16 authors.
Yu LiangDepartment of Developmental Cell Biology, Key Laboratory of Cell Biology, Ministry of Public Health, and Key Laboratory of Medical Cell Biology, Ministry of Education China Medical University Shenyang China.ORCID 0009-0007-4321-2766 Dan ZhaoDepartment of Developmental Cell Biology, Key Laboratory of Cell Biology, Ministry of Public Health, and Key Laboratory of Medical Cell Biology, Ministry of Education China Medical University Shenyang China.
Peng-Fei WuDepartment of Neurosurgery the First Affiliated Hospital of China Medical University Shenyang China.
Yong-Qi LiangDepartment of Developmental Cell Biology, Key Laboratory of Cell Biology, Ministry of Public Health, and Key Laboratory of Medical Cell Biology, Ministry of Education China Medical University Shenyang China.ORCID 0009-0006-6521-452X Xue-Wei ZhangDepartment of Developmental Cell Biology, Key Laboratory of Cell Biology, Ministry of Public Health, and Key Laboratory of Medical Cell Biology, Ministry of Education China Medical University Shenyang China.ORCID 0009-0004-9714-1463 Jia XingDepartment of Histology and Embryology, School of Basic Medicine China Medical University Shenyang China.ORCID 0000-0001-7521-9806 Xue SunDepartment of Developmental Cell Biology, Key Laboratory of Cell Biology, Ministry of Public Health, and Key Laboratory of Medical Cell Biology, Ministry of Education China Medical University Shenyang China.ORCID 0009-0001-9384-8013 Ming-Xin AnDepartment of Developmental Cell Biology, Key Laboratory of Cell Biology, Ministry of Public Health, and Key Laboratory of Medical Cell Biology, Ministry of Education China Medical University Shenyang China.ORCID 0009-0007-2730-4484 Jun-Xiu ShiDepartment of Developmental Cell Biology, Key Laboratory of Cell Biology, Ministry of Public Health, and Key Laboratory of Medical Cell Biology, Ministry of Education China Medical University Shenyang China.ORCID 0000-0003-2457-1820 Qing-Hua GaoDepartment of Developmental Cell Biology, Key Laboratory of Cell Biology, Ministry of Public Health, and Key Laboratory of Medical Cell Biology, Ministry of Education China Medical University Shenyang China.ORCID 0000-0002-4362-2817 Bin XueJiangsu Key Laboratory of Early Development and Chronic Diseases Prevention in Children Nanjing Medical University Nanjing China.ORCID 0000-0002-2713-2156 Li-Bo JiangDepartment of Hematology The Second Affiliated Hospital of Qiqihar Medical University Qiqihar China.ORCID 0009-0000-3409-6934 Yu-Hua ChenDepartment of Developmental Cell Biology, Key Laboratory of Cell Biology, Ministry of Public Health, and Key Laboratory of Medical Cell Biology, Ministry of Education China Medical University Shenyang China.ORCID 0000-0003-1984-2892 Wei-Dong ZhaoDepartment of Developmental Cell Biology, Key Laboratory of Cell Biology, Ministry of Public Health, and Key Laboratory of Medical Cell Biology, Ministry of Education China Medical University Shenyang China.ORCID 0000-0003-0029-4400 Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
backgroundCommunication between the vascular endothelium and peripheral leukocytes is an important process controlling inflammatory responses in the brain. Increased plasma levels of CTSD (cathepsin D) have been associated with vascular events, but whether circulating CTSD may affect the functional status of the endothelium remains unknown.
methodsTo resolve this issue, two groups of transgenic hCTSD
resultsWe found the hCTSD
conclusionsTaken together, these results demonstrate that circulating prototype CTSD exacerbates the injury-induced brain damage by upregulating brain endothelial VCAM-1 and promoting neutrophil transmigration into the brain.
Indexed as
BrainBrain Injuries, TraumaticBrain IschemiaCathepsin DNeutrophil InfiltrationNeutrophilsAnimalsDisease Models, AnimalEndothelium, VascularMaleMiceMice, Inbred C57BLMice, KnockoutMice, TransgenicCathepsin Dbrain endothelial cellsbrain injurycathepsin Dneutrophil infiltrationVCAM‐1
Identifiers
PMID41147378
PMCPMC12684490
What Socratic holds
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