ArticleJournal of the American Heart Association2025
Prior Dual Antiplatelet Therapy and Mortality After Intracerebral Hemorrhage: A Danish Nationwide Cohort Study.
Article in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Risk and Timing of Intracerebral Hemorrhage Expansion Among Patients Treated with Antithrombotic Agents.Neurocritical care · 2026Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLimited data support the link between dual antiplatelet therapy (DAPT) and adverse outcome among patients with intracerebral hemorrhage. This study aimed to investigate the association between prior use of DAPT and mortality after intracerebral hemorrhage.
methodsPatients with first-ever intracerebral hemorrhage on current APT at the time of admission, were identified and followed 180 days after admission through the Danish nationwide registries. Prior exposure to DAPT or single APT (SAPT) was established through the Danish National Prescription Registry. Inverse probability of treatment weighting was used to control for confounding.
resultsA total of 5800 patients were on antiplatelet therapy. 5535 (95.4%) were on SAPT, and 265 (4.6%) were on DAPT. Compared with patients on SAPT, patients on DAPT more commonly had a history of ischemic stroke or transient ischemic attack (134 [50.6%] versus 2393 [43.2%]), ischemic heart disease (172 [64.9%] versus 1561 [28.2%]), congestive heart failure (57 [21.5%] versus 505 [9.1%]) or chronic kidney disease (25 [9.4%] versus 205 [3.7%]). The 180-day cumulative mortality rate was 52.6% for patients on DAPT and 45.6% for patients on SAPT (
conclusionsAmong patients with intracerebral hemorrhage, prior DAPT was found to be associated with a higher mortality compared with SAPT.
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