ArticlemBio2025
Epithelial transcription factor Elf3 mediates host immune responses to microbiota and protects against aerocystitis in zebrafish.
Briana R Davis, Colin R Lickwar, Christiane V Löhr, Jia Wen, Margaret Morash, Mollie I Sweeney, Elizabeth L Reich, Peyton J Moore, David M Tobin, John F Rawls
Abstract read
In one paragraphArticle in mBio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
10 authors.
Briana R DavisDepartment of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, North Carolina, USA.ORCID 0000-0003-0109-7441 Colin R LickwarDepartment of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, North Carolina, USA.
Christiane V LöhrOregon Veterinary Diagnostic Laboratory, Carlson College of Veterinary Medicine, Oregon State University, Corvallis, Oregon, USA.
Jia WenDepartment of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, North Carolina, USA.
Margaret MorashDepartment of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, North Carolina, USA.
Mollie I SweeneyDepartment of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, North Carolina, USA.
Elizabeth L ReichDepartment of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, North Carolina, USA.
Peyton J MooreDepartment of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, North Carolina, USA.
David M TobinDepartment of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, North Carolina, USA.ORCID 0000-0003-3465-5518 John F RawlsDepartment of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, North Carolina, USA.ORCID 0000-0002-5976-5206 Funding
Role of IL-10 in APC Regulation of Protective vs. Pathogenic T Cell Responses toP01DK094779 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SARTOR, RYAN B · 2013 to 2023
$17.9MIdentifying genes required for digestive physiology and lipid metabolismR01DK093399 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI STEVEN A FARBER, John F Rawls · 2013 to 2026
$7.6MMedical Scientist Training Program Training GrantT32GM145449 · NIGMS · DUKE UNIVERSITY · PI Christopher D Kontos · 2022 to 2026
$6.6MMacrophage Reprogramming During Granuloma Formation in the ZebrafishR01AI130236 · NIAID · DUKE UNIVERSITY · PI David M. Tobin · 2017 to 2026
$4.5MMechanisms of Enteroendocrine Cell Adaptation to High Fat Diet in ZebrafishF30DK135357 · NIDDK · DUKE UNIVERSITY · PI Margaret Morash · 2023 to 2026
$180kNIAID NIH HHS R01 AI130236NIDDK NIH HHS F30 DK135357NIDDK NIH HHS P01 DK094779NIDDK NIH HHS R01 DK093399NIGMS NIH HHS T32 GM145449
6 · The paper itselfAbstract
Animals defend against infections and other diseases by adaptively responding to the microbiota they encounter. These adaptations are driven by changes in gene expression programs; however, our understanding of the transcription factors regulating host responses to microbiota remains limited. By leveraging gene expression and chromatin accessibility data from zebrafish and mice, we identified the epithelial-specific E74-like ETS transcription factor 3 (
Indexed as
Host Microbial InteractionsMicrobiotaProto-Oncogene Proteins c-etsTranscription FactorsZebrafishZebrafish ProteinsAnimalsDNA-Binding ProteinsGene Expression ProfilingLarvaMiceDNA-Binding ProteinsProto-Oncogene Proteins c-etsTranscription FactorsZebrafish ProteinsaerocystitisaxenicElf3functional genomicsgerm-freegnotobioticshost-microbial interactioninnate immunitysymbiosistranscriptional regulationtranscription factorzebrafish
Identifiers
PMID41147741
PMCPMC12691682
What Socratic holds
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