ArticleVeterinary medicine and science2025
Evaluation of Endothelial Glycocalyx Damage in Neonatal Lambs With Diarrhoea: A Biomarker-Based Approach.
Article in Veterinary medicine and science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Case series of neonatal lamb diarrhea syndrome treated with an evidence-based protocol to reduce antibacterial use.Veterinary research communications · 2026Article
- Evaluation of Endothelial Glycocalyx Damage in Neonatal Lambs With Diarrhoea: A Biomarker-Based Approach.Veterinary medicine and science · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
backgroundNeonatal diarrhoea is one of the most common diseases in lambs, causing economic losses and welfare issues. The endothelial glycocalyx (eGC) plays a crucial role in vascular integrity and inflammatory regulation. However, its involvement in neonatal lamb diarrhoea remains unclear.
objectivesThis study aimed to evaluate eGC damage in neonatal lambs with diarrhoea by assessing biomarkers, including nitric oxide (NO), heparan sulphate (HS), angiopoietin-2 (Ang-2) and A disintegrin and metalloproteinase 15 (ADAM15).
methodsA total of 68 neonatal lambs with diarrhoea (39 infected with Escherichia coli and 29 with Cryptosporidium parvum) and 20 healthy controls were included. Diarrhoea aetiology was confirmed via faecal antigen tests and microscopic examination. Blood samples were collected for hemogram and biomarker analysis using sheep-specific ELISA kits. RESULTS AND
conclusionsLambs with diarrhoea showed significantly higher total leukocyte (white blood cell [WBC]), granulocyte (GRA) and monocyte (MON) counts (p < 0.01). Serum NO concentrations were significantly elevated in lambs with diarrhoea, whereas HS and Ang-2 concentrations were lower (p < 0.01). E. coli-infected lambs had significantly higher ADAM15 concentrations than those with Cryptosporidium infection (p < 0.001). These findings suggest that NO may have a protective and/or anti-inflammatory role in neonatal lamb diarrhoea, potentially maintaining eGC integrity despite the inflammatory process.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.