ArticleJournal of gastroenterology2026
Clinical manifestations of immunoglobulin G4-related gastrointestinal disease: a nationwide multicenter retrospective study.
Article in Journal of gastroenterology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Immunoglobulin G4-Related Disease-Like Gastric Lesion Presenting as Submucosal Tumor-Like Lesions.DEN open · 2026Article
- Article
- A Rare Case of Gastritis with Prominent IgG4-Positive Plasmacytosis Mimicking IgG4-Related Gastrointestinal Disease.Inflammatory intestinal diseasesArticle
Corrections and comments
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Authors and funding
18 authors.
Funding
Abstract
backgroundImmunoglobulin G4 (IgG4)-related gastrointestinal diseases (IgG4-GID) are becoming increasingly recognized. However, few cases have been reported, and the disease concept is not yet well established. This study aimed to elucidate the clinical features of IgG4-GID.
methodsThis nationwide multicenter retrospective study collected 37 cases of IgG4-GID, which were classified and analyzed based on the pathological findings and the presence or absence of IgG4-related diseases in other organs. The pathological possibility of IgG4-GID was classified as definite, highly likely, probable, or unlikely based on the presence of typical pathological findings, number of IgG4-positive cells, and adequacy of histological evaluation.
resultsThirteen patients were classified as unlikely to undergo pathological evaluation. Among the remaining 24 cases, 20 had other organ involvement (pathologically definite, n = 8; highly likely, n = 6; probably, n = 6). The four cases without the involvement of other organs were classified as definite. After defining definite and highly likely cases, 18 cases of IgG4-GID were identified. The most commonly affected organs were the stomach (n = 12) and the duodenum (n = 6), with one case involving both. Endoscopic findings most frequently showed ulcers (n = 7), followed by submucosal tumor (SMT)-like morphology (n = 6). Treatments included surgery (n = 8; SMT-like cases), steroids (n = 2), and proton pump inhibitors or potassium-competitive acid blockers (n = 3), with all cases showing improvement.
conclusionsIgG4-GID exhibits characteristic pathological findings and various endoscopic features. Although many patients respond to treatment, some undergo surgery; thus, increased awareness may help avoid unnecessary surgeries.
Indexed as
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.