ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2025
Dynamic changes in nutritional parameters, inflammatory, and immune biomarkers during (chemo-) radiotherapy for head and neck cancer: a prospective longitudinal study.
Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Dynamic changes in nutrition and inflammatory parameters: what can we surmise.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Article
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Abstract
purposeTo comprehensively investigate the dynamic changes and correlations among nutritional parameters, inflammatory, and immune biomarkers for head and neck cancer (HNC) patients during (chemo-)radiotherapy.
methodsBody composition measurements, subjective nutritional assessments, and hematological biomarkers were prospectively evaluated at four time points: pre-radiotherapy (T1), mid-radiotherapy (T2), at the completion of radiotherapy (T3), and 1 month afterward (T4).
resultsA total of 65 patients completed four follow-ups. Longitudinal analysis revealed statistically significant differences (all P < 0.05) in nutritional, inflammatory, and immune parameters across the four time points (T1-T4). Nutritional parameters including body weight, body mass index, fat-free mass, soft lean mass, skeletal muscle mass, body fat mass, handgrip strength, Nutritional Risk Screening 2002 (NRS2002) score, Patient-Generated Subjective Global Assessment (PG-SGA) score, Karnofsky Performance Status (KPS) score, daily energy intake, daily protein intake, albumin, total protein, prealbumin, hemoglobin, platelet, and red blood cell count all demonstrated significant temporal changes. Similarly, inflammatory/immune biomarkers including white blood cell count, neutrophil count, lymphocyte count, T-lymphocyte count, B-lymphocyte count, C-reactive protein, procalcitonin, interleukin-6, interleukin-10, interferon-γ, and tumor necrosis factor-α showed significant fluctuations during radiotherapy. Spearman's correlation analysis demonstrated associations among nutritional parameters, inflammatory, and immune biomarkers at T3 (all P < 0.05).
conclusionOur prospective study demonstrates that patients with HNC experience progressive deterioration in nutritional status (particularly fat-free mass loss) during (chemo-)radiotherapy, which is accompanied by heightened inflammatory responses and diminished immune function. These findings strongly support the integration of multimodal nutritional-inflammatory-immune monitoring protocols into routine oncologic care throughout radiotherapy.
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