Evidence map›Paper›PMID 41148416›Full record

ArticleEJNMMI radiopharmacy and chemistry2025

[

Woochan Kim, Aaron K Wozniak, Nathaniel J Burkard, Michael L Freaney, Ailen Costamagna-Soto, Kelly A O'Conor, Abolghasem Bakhoda, Seth M Eisenberg, Wenjing Zhao, Jeih-San Liow and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EJNMMI radiopharmacy and chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

  • Update of
    [2025
5 · Who and what money

Authors and funding

12 authors.

Woochan KimLaboratory of Neuroimaging, National Institute On Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, 20892, USA.
Aaron K Wozniak *Laboratory of Neuroimaging, National Institute On Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, 20892, USA.
Nathaniel J Burkard *Laboratory of Neuroimaging, National Institute On Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, 20892, USA.
Michael L FreaneyLaboratory of Neuroimaging, National Institute On Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, 20892, USA.
Ailen Costamagna-SotoLaboratory of Neuroimaging, National Institute On Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, 20892, USA.
Kelly A O'ConorLaboratory of Neuroimaging, National Institute On Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, 20892, USA.
Abolghasem BakhodaLaboratory of Neuroimaging, National Institute On Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, 20892, USA.
Seth M EisenbergLaboratory of Neuroimaging, National Institute On Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, 20892, USA.
Wenjing ZhaoLaboratory of Neuroimaging, National Institute On Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, 20892, USA.
Jeih-San LiowMolecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, 20892, USA.
Nora D VolkowLaboratory of Neuroimaging, National Institute On Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, 20892, USA. nvolkow@nida.nih.gov.
Sung Won KimLaboratory of Neuroimaging, National Institute On Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, 20892, USA. sunny.kim@nih.gov.ORCID http://orcid.org/0000-0002-4647-4899

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFentanyl is a potent synthetic opioid widely used for pain management and anesthesia, but the high prevalence of its misuse and its key contribution to overdose fatalities in the United States have made it a major drug of concern. Although fentanyl's onset, duration, and toxicity depend on its pharmacokinetics and specific tissue distribution, most studies have focused primarily on plasma concentrations, leaving its distribution in critical tissues largely unexplored (this knowledge gap limits our understanding of fentanyl's clinical effects, tissue accumulation, and the factors influencing its efficacy and safety). Here, we report the radiosynthesis of [

results[

conclusionsWe successfully developed and automated the radiosynthesis of [

Indexed as

Carbon-11FentanylPharmacokineticsPositron emission tomography

Identifiers

PMID41148416
PMCPMC12569255

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.