Evidence map›Paper›PMID 41148599›Full record

ArticleAsian Pacific journal of cancer prevention : APJCP2025

Oxidative Stress Dynamic among Helicobacter pylori-Positive Patients with Various Stages of Premalignant Histologic Lesions: A Prospective Study in Cameroon.

Laure Brigitte Kouitcheu Mabeku, Faujo Nintewoue Ghislaine Florice, Lionel Dannyl Tali Nguefak, Isabelle Ndang Timba, Ghislaine Ngatcha, Sartre Michele Tagni, Paul Talla, Carole Marlyse Menzy Moungo-Ndjole

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Article in Asian Pacific journal of cancer prevention : APJCP, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Laure Brigitte Kouitcheu MabekuMicrobiology and Pharmacology Laboratory, Department of Biochemistry, Faculty of Science, University of Dschang, Dschang, Cameroon.
Faujo Nintewoue Ghislaine FloriceMicrobiology and Pharmacology Laboratory, Department of Biochemistry, Faculty of Science, University of Dschang, Dschang, Cameroon.
Lionel Dannyl Tali NguefakMicrobiology and Pharmacology Laboratory, Department of Biochemistry, Faculty of Science, University of Dschang, Dschang, Cameroon.
Isabelle Ndang TimbaRegional Hospital Bafoussam, Bafoussam, Cameroon.
Ghislaine NgatchaCentre Médicale la Cathédrale, Yaoundé, Cameroon.
Sartre Michele TagniCentre Médicale la Cathédrale, Yaoundé, Cameroon.
Paul TallaGeneral Hospital Yaoundé, Yaoundé, Cameroon.
Carole Marlyse Menzy Moungo-NdjoleGeneral Hospital Yaoundé, Yaoundé, Cameroon.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis study sought to evaluate biomarkers of oxidative stress among H pylori infected patients in relation to neoplastic transformation within the gastric mucosa.

methodsThis study included 191 H. pylori-positive patients: 14 healthy individuals, 40 with chronic gastritis, 69 with atrophic gastritis, 22 with intestinal metaplasia, and 46 with dysplasia. H. pylori was detected on biopsies samples. Hematein/eosin staining was used for the histologic examination of gastric mucosa. Reduced glutathione (GHS) and malondialdehyde (MAD) content, activity of superoxide dismutase (SOD) and catalase (CAT) were measured in serum.

resultsThe serum levels of GSH were higher among patients with chronic gastritis (P = 0.0277), atrophic gastritis (P = 0.0451), and dysplasia (P = 0.0069) compared to the controls. The highest concentration of GHS was recorded in dysplasia (P = 0.0157). The content of lipid peroxidation products (MAD) significantly increased in patients with gastric pre-malignancies compared to the controls (P ˂ 0.0001). SOD activity was higher among patients with gastric mucosa injury compared to the controls, with the highest concentration in metaplasia (P = 0.0182). Catalase activity was similar to that of superoxide dismutase (P> 0.05).

conclusionOur findings showed significant higher and progressive serum levels of lipid peroxidation and antioxidant protective factors with progression in precancerous lesions related to H. pylori infection. This suggests a higher free radical formation and oxidative stress, which increases from chronic gastritis to malignancy.

Indexed as

Gastric MucosaGastritisGastritis, AtrophicHelicobacter InfectionsHelicobacter pyloriOxidative StressPrecancerous ConditionsStomach NeoplasmsAdultCameroonCase-Control StudiesCatalaseFemaleFollow-Up StudiesHumansMaleCatalaseMalondialdehydeSuperoxide DismutaseCatalase activityMalondialdehyde contentReduced glutathione contentsuperoxide dismutase activity

Identifiers

PMID41148599
PMCPMC12894789

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