Evidence map›Paper›PMID 41148623›Full record

ArticleAsian Pacific journal of cancer prevention : APJCP2025

Association of IFNL4 and IFITM3 Genetic Variants with Susceptibility to HCV-Related Liver Cirrhosis and Hepatocellular Carcinoma.

Enas Ahmed Osman, Marwa Ahmed Mohamed, Rania M Abbas, Ethar Mokhtar Badran, Heba I Aly, Medhat M Madbouly, Farida M Khanany

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Article in Asian Pacific journal of cancer prevention : APJCP, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

7 authors.

Enas Ahmed OsmanClinical Chemistry Department, Theodor Bilharz Research Institute, Giza, Egypt.ORCID 0000-0002-8217-2265
Marwa Ahmed MohamedAin Shams University, Cairo, Egypt.
Rania M AbbasAin Shams University, Cairo, Egypt.
Ethar Mokhtar BadranAin Shams University, Cairo, Egypt.
Heba I AlyAin Shams University, Cairo, Egypt.
Medhat M MadboulyClinical Chemistry Department, Theodor Bilharz Research Institute, Giza, Egypt.
Farida M KhananyClinical Chemistry Department, Theodor Bilharz Research Institute, Giza, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo ascertain the possible association of IFITM3 rs12252 and IFNL4 rs12979860 genetic polymorphisms with cirrhosis and HCC in chronic HCV-infected patients.

methodsGenetic variations were assessed in this case-control study using TaqMan real-time polymerase chain reaction (RT-PCR) in 1350 subjects: 450 healthy controls, 450 cirrhosis patients, and 450 patients with HCC.

resultsThe genotyping of the IFNL4 rs12979860 revealed a significantly higher frequency of the TT genotype in the cirrhotic group compared to healthy controls. Additionally, the proportions of the CT genotype and TT genotypes were significantly higher in the HCC patients than in the healthy controls. Regarding the IFITM3 rs12252, the frequency of the CC genotype was significantly higher in the cirrhotic group compared to healthy controls. The proportion of the CT and CC genotypes in the HCC group was significantly higher than in healthy controls.

conclusionOur results indicate that the IFITM3 rs12252 and IFNL4 rs12979860 genetic polymorphisms are linked to the development of cirrhosis and HCC in patients chronically infected with HCV.

Indexed as

Carcinoma, HepatocellularHepatitis C, ChronicInterferon LambdaLiver CirrhosisLiver NeoplasmsRNA-Binding ProteinsCase-Control StudiesFemaleGenetic Predisposition to DiseaseGenotyping TechniquesHumansInterleukinsMaleMembrane ProteinsPolymorphism, Single NucleotideIFITM3 protein, humanIFNL4 protein, humanInterferon LambdaInterleukinsMembrane ProteinsRNA-Binding Proteinscirrhosisgenetic polymorphismsHepatitis C VirusHepatocellular carcinomaliver disorders

Identifiers

PMID41148623
PMCPMC12906777

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LicenceCC BY-NC
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