ArticleCells2025
Description of T-Cell and Monocyte Populations in the Circulation of People with HIV Prior to AIDS-NHL Diagnosis.
Laura E Martínez, Begoña Comin-Anduix, Miriam Güemes-Aragon, Javier Ibarrondo, Roger Detels, Matthew J Mimiaga, Marta Epeldegui
Abstract read
In one paragraphArticle in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
7 authors.
Laura E MartínezUCLA AIDS Institute, University of California, Los Angeles, CA 90095, USA.
Begoña Comin-AnduixJonsson Comprehensive Cancer Center, University of California, Los Angeles, CA 90095, USA.
Miriam Güemes-AragonJonsson Comprehensive Cancer Center, University of California, Los Angeles, CA 90095, USA.
Roger DetelsDepartment of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, CA 90095, USA.
Matthew J MimiagaDepartment of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, CA 90095, USA.
Funding
Women's CancersP30CA016042 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Robert Damoiseaux · 1985 to 2026
$134.5MUCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1MVirology CoreP30AI028697 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ZACK, JEROME A. · 1991 to 2018
$39.9MSex differences in the role of multi-omicsin HIV-associated carotid artery atherosclerosisU01HL146193 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI Stephen J Gange, Elizabeth Topper · 2019 to 2026
$35.8MStudy of Hearing and Balance in Middle Aged and Aging Men and Women in the MACS-WIHS Combined Cohort StudyU01HL146333 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Roger Detels, Matthew James Mimiaga · 2019 to 2026
$32.2MUCLA Tumor Immunology Training ProgramT32CA009120 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Steven M. Dubinett, MICHAEL A TEITELL · 1985 to 2026
$10.3MThe Role of Follicular CD8+ T Cells in Pathogenesis of AIDS-NHL.R01CA228157 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI EPELDEGUI, MARTA · 2019 to 2023
$1.8MMucosal B-cell aging in PLWHR56AG086059 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI EPELDEGUI, MARTA, YANG, OTTO O · 2024 to 2024
$393kPDL1 expression on B cells: a potential marker of pre-tumor cells in AIDS-NHLR21CA220475 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI EPELDEGUI, MARTA · 2017 to 2018
$372kJames B. Pendleton Charitable Trust 0McCarthy Family Foundation 0NCATS NIH HHS UL1 TR001881NCI NIH HHS P30 CA016042NCI NIH HHS R01 CA228157NCI NIH HHS R21 CA220475NCI NIH HHS T32 CA009120NHLBI NIH HHS U01 HL146193NHLBI NIH HHS U01 HL146333NIAID NIH HHS P30 AI028697NIA NIH HHS R56 AG086059NIH HHS 1P30AI028697-00NIH HHS 1P30CA016042-00NIH HHS 1R01CA228157-02NIH HHS 1R01CA228157-05NIH HHS 1R21CA220475-02NIH HHS 1R56AG086059-01NIH HHS 1T32CA009120-02
6 · The paper itselfAbstract
People with HIV (PWH) are at an increased risk for AIDS-associated non-Hodgkin lymphoma (AIDS-NHL); however, the immune signatures underlying this risk are not well understood. In this study, we utilized mass cytometry by time-of-flight (CyTOF) to analyze T-cells and monocytes in the PBMCs of treatment-naïve PWH, including those 3 to 36 months before an AIDS-NHL diagnosis (HIV-positive pre-NHL), as well as people without HIV (PWoH). Mass cytometry is an advanced single-cell analysis platform that combines flow cytometry principles with mass spectrometry. Unlike conventional flow cytometry, this technology employs antibodies conjugated to unique metal isotopes instead of fluorescent markers, enabling simultaneous measurement of over 40 distinct cellular markers per individual cell without spectral overlap limitations. Participants were enrolled at the Los Angeles site of the MACS/WIHS Combined Cohort Study (MWCCS). Unsupervised clustering and Uniform Manifold Approximation and Projection (UMAP) analysis identified CD3
Indexed as
Acquired Immunodeficiency SyndromeHIV InfectionsLymphoma, Non-HodgkinMonocytesT-LymphocytesAdultFemaleFlow CytometryHumansMaleMiddle AgedAIDS-NHLCD14+ monocytesCD20+ T-cellsHIVpre-lymphomaunsupervised clustering analysis
Identifiers
PMID41148820
PMCPMC12564559
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