Evidence map›Paper›PMID 41149045›Full record

ReviewDiseases (Basel, Switzerland)2025

Chronic Hepatitis B: Current Management and Future Directions.

Hamza Ertugrul, Esra Ekiz, Sibel Islak Mutcali, Veysel Tahan, Ebubekir Daglilar

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Diseases (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Hamza ErtugrulTrinity Health of New England, St. Mary's Hospital, 56 Franklin Street, Waterbury, CT 06706, USA.
Esra EkizTrinity Health of New England, St. Mary's Hospital, 56 Franklin Street, Waterbury, CT 06706, USA.
Sibel Islak MutcaliVandalia Health, Charleston Area Medical Center (CAMC), 3100 MacCorkle Ave. SE, Charleston, WV 25304, USA.ORCID 0000-0003-2392-0910
Veysel TahanVandalia Health, Charleston Area Medical Center (CAMC), 3100 MacCorkle Ave. SE, Charleston, WV 25304, USA.ORCID 0000-0001-6796-9359
Ebubekir DaglilarVandalia Health, Charleston Area Medical Center (CAMC), 3100 MacCorkle Ave. SE, Charleston, WV 25304, USA.ORCID 0000-0003-0622-1704

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic hepatitis B virus (HBV) infection remains a major global health burden, affecting millions and contributing significantly to liver-related morbidity and mortality. While substantial progress has been made in elucidating the virology and natural history of HBV, the management of chronic hepatitis B (CHB) continues to present clinical challenges. The development of potent nucleos(t)ide analogs and pegylated interferon has improved viral suppression and delayed disease progression, yet a definitive cure remains elusive due to the persistence of covalently closed circular DNA (cccDNA). Recent research has focused on novel antiviral agents, immunomodulatory therapies, and combination strategies aimed at achieving a functional cure. This review summarizes current therapeutic approaches, recent advancements, and emerging directions in CHB management.

Indexed as

capsid assembly modulators (CAMs)covalently closed circular DNA (cccDNA)farnesoid X receptor (FXR) agonistsfunctional cureHBsAg release inhibitorshepatitis B virus (HBV)nucleot(s)ide analogs (NAs)pegylated interferon alpha (PegIFNα)

Identifiers

PMID41149045
PMCPMC12563165

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.