Evidence map›Paper›PMID 41149489›Full record

ArticleCurrent oncology (Toronto, Ont.)2025

Small Extracellular Vesicles Derived from NF2-Associated Schwannoma Cells Modulate Tumor Progression and Immunity via HSP90.

Ying Wang, Yuan Ren, Qi Zhang, Chao Zhang, Minjun Yan, Xin Ma, Bo Wang, Peng Li, Pinan Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current oncology (Toronto, Ont.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ying WangDepartment of Neural Reconstruction, Beijing Neurosurgical Institute, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China.
Yuan RenDepartment of Neurosurgery, Beijing Tsinghua ChangGung Hospital, School of Clinical Medicine, Tsinghua University, Beijing 102218, China.
Qi ZhangDepartment of Ultrastructural Pathology, The Neuropathology Center, Beijing Neurosurgical Institute, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China.
Chao ZhangDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China.
Minjun YanDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China.
Xin MaDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China.
Bo WangDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China.
Peng LiDepartment of Neural Reconstruction, Beijing Neurosurgical Institute, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China.
Pinan LiuDepartment of Neural Reconstruction, Beijing Neurosurgical Institute, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China.ORCID 0000-0002-6479-7376

Funding

Beijing Municipal Natural Science Foundation L222015Beijing Municipal Science and Technology Project (2022) Z221100007422041National Natural Science Foundation of China 82373451 and 81502453The Public Welfare Development and the Public Welfare Development and Reform Pilot Project of Beijing Medical Research Institute JYY2023-2
6 · The paper itself

Abstract

In-depth exploration of tumor immune suppression mechanisms may provide new therapeutic options for NF2-associated tumors. In this study, we found that sEVs secreted by NF2-associated schwannomas (NF2-EVs) facilitate the conversion of CD14

Indexed as

Extracellular VesiclesHSP90 Heat-Shock ProteinsNeurilemmomaNeurofibromatosis 2Neurofibromin 2AnimalsCell Line, TumorCell ProliferationDisease ProgressionHumansMiceTumor MicroenvironmentHSP90 Heat-Shock ProteinsNeurofibromin 2AKTexosomeHSP90MDSCNF2-related schwannomatosis (NF2-SWN)

Identifiers

PMID41149489
PMCPMC12563180

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.