Evidence map›Paper›PMID 41150463›Full record

ReviewVaccines2025

Construction and Research Progress of Animal Models and Mouse Adapted Strains of Seasonal Influenza Virus.

Haijun Zhu, Siyu Pu, Peiqing He, Junhao Luo, Rongbao Gao

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Vaccines, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Haijun ZhuDepartment of Health Inspection and Quarantine, School of Public Health, Public Health College, Anhui Medical University, Hefei 230032, China.ORCID 0009-0005-9736-3848
Siyu PuNHC Key Laboratory of Biosafety, NHC Key Laboratory of Medical Virology and Viral Diseases, Chinese National Influenza Center, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
Peiqing HeNHC Key Laboratory of Biosafety, NHC Key Laboratory of Medical Virology and Viral Diseases, Chinese National Influenza Center, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
Junhao LuoNHC Key Laboratory of Biosafety, NHC Key Laboratory of Medical Virology and Viral Diseases, Chinese National Influenza Center, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
Rongbao GaoDepartment of Health Inspection and Quarantine, School of Public Health, Public Health College, Anhui Medical University, Hefei 230032, China.ORCID 0000-0003-1139-3607

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Influenza viruses, featured by high variability, pose a persistent public health threat because of an annual seasonal epidemic in the world and irregular global pandemic, requiring animal models to elucidate their pathogenic mechanisms and advance preventive strategies. Mice have been selected as the primary animal model, although several experimental animals have been used in studies of the influenza virus. However, the limited susceptibility of wild-type influenza viruses to mice poses significant challenges for studying pathogenesis and intervention strategies. Here, to help understand the construction of mouse-adapted influenza viruses, we reviewed the recent research progress in constructing mouse-adapted influenza virus strains to overcome species-specific barriers.

Indexed as

influenzamouse adaptationpolymerase complexreverse geneticsvaccine evaluationviral pathogenesis

Identifiers

PMID41150463
PMCPMC12567564

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.