Evidence map›Paper›PMID 41150549›Full record

ArticleToxics2025

Absorption and Tissue Distribution of Environmental Pollutant HFPO-DA, and Its Effect on Hepatic Lipid Metabolism Reprogramming in Mice.

Jie Peng, Wei Jiang, Zi Long, Yueying Cui, Guizhen Zhu, Rui Liu, Deqin Kong, Weihua Yu, Yuliang Li, Chunxu Hai

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jie PengDepartment of Toxicology, The Shaanxi Provincial Key Laboratory of Free Radical Biology and Medicine, The Shaanxi Provincial Key Laboratory of Environmental Health Hazard Assessment and Protection, The Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, School of Public Health, The Fourth Military Medical University, Xi'an 710032, China.
Wei JiangDepartment of Pharmacy, The Second Affiliated Hospital, The Fourth Military Medical University, Xi'an 710038, China.ORCID 0000-0003-0744-1004
Zi LongDepartment of Aeromedical Support & Flight Safety, Air Force Medical Center, The Fourth Military Medical University, Beijing 100142, China.
Yueying CuiDepartment of Clinical Medicine Laboratory, Air Force Medical Center, The Fourth Military Medical University, Beijing 100142, China.
Guizhen ZhuDepartment of Clinical Medicine Laboratory, Air Force Medical Center, The Fourth Military Medical University, Beijing 100142, China.
Rui LiuDepartment of Toxicology, The Shaanxi Provincial Key Laboratory of Free Radical Biology and Medicine, The Shaanxi Provincial Key Laboratory of Environmental Health Hazard Assessment and Protection, The Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, School of Public Health, The Fourth Military Medical University, Xi'an 710032, China.
Deqin KongDepartment of Toxicology, The Shaanxi Provincial Key Laboratory of Free Radical Biology and Medicine, The Shaanxi Provincial Key Laboratory of Environmental Health Hazard Assessment and Protection, The Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, School of Public Health, The Fourth Military Medical University, Xi'an 710032, China.
Weihua YuDepartment of Toxicology, The Shaanxi Provincial Key Laboratory of Free Radical Biology and Medicine, The Shaanxi Provincial Key Laboratory of Environmental Health Hazard Assessment and Protection, The Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, School of Public Health, The Fourth Military Medical University, Xi'an 710032, China.
Yuliang LiDepartment of Aeromedical Support & Flight Safety, Air Force Medical Center, The Fourth Military Medical University, Beijing 100142, China.
Chunxu HaiDepartment of Toxicology, The Shaanxi Provincial Key Laboratory of Free Radical Biology and Medicine, The Shaanxi Provincial Key Laboratory of Environmental Health Hazard Assessment and Protection, The Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, School of Public Health, The Fourth Military Medical University, Xi'an 710032, China.

Funding

The Air Force Medical Center's Scientific Research Advancement Project 2025The Fourth Military Medical University Talent Program Item 2025
6 · The paper itself

Abstract

objectiveHexafluoropropylene oxide dimer acid (HFPO-DA), also known as GenX, is widely used globally, raising concerns about its safety and public health implications. However, its toxicity mechanism remains unclear. The purpose of this study was to develop a reliable method for detecting HFPO-DA in mice and to investigate its absorption, distribution, and impact on hepatic lipid metabolism.

methodHFPO-DA levels were measured in the serum and eight tissues of C57BL/6J mice after oral administration using ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). Lipid metabolites in the liver were also detected and analyzed.

resultsHFPO-DA was rapidly absorbed into the bloodstream and widely distributed throughout all tested tissues. It penetrated the blood-brain barrier, with the highest concentration in the liver; however, long-term effects on the lungs also warrant attention. HFPO-DA disrupted liver lipid metabolism, leading to acylcarnitine accumulation while lowering triglycerides and cholesterol.

conclusionThis study on the pharmacokinetics and tissue distribution of HFPO-DA in mice following oral exposure revealed that HFPO-DA exacerbates liver injury by altering hepatic lipid metabolism. These findings provide theoretical support for toxicological studies on the emerging environmental pollutant HFPO-DA.

Indexed as

HFPO-DAlipid metabolismpharmacokineticstissue distributionUPLC-HRMS

Identifiers

PMID41150549
PMCPMC12568254

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.