Evidence map›Paper›PMID 41150714›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

A functional clock in only two dorsal clock neurons is sufficient to restore the basal circadian activity pattern of

Nils Reinhard, Enrico Bertolini, Takuya Kuwahara, Manabu Sekiguchi, Dirk Rieger, Weihua Li, Paul H Taghert, Taishi Yoshii, Charlotte Helfrich-Förster

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Journal of biological rhythms · 2026
    Article
  3. Clock-related neuropeptides inFrontiers in genetics · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Nils ReinhardNeurobiology and Genetics, Theodor-Boveri-Institute, Biocentre, Julius-Maximilians-University of Würzburg, Würzburg 97074, Germany.ORCID 0000-0002-7989-7150
Enrico BertoliniNeurobiology and Genetics, Theodor-Boveri-Institute, Biocentre, Julius-Maximilians-University of Würzburg, Würzburg 97074, Germany.ORCID 0000-0002-7573-7467
Takuya KuwaharaGraduate School of Natural Science and Technology, Okayama University, Okayama 700-8530, Japan.
Manabu SekiguchiGraduate School of Natural Science and Technology, Okayama University, Okayama 700-8530, Japan.
Dirk RiegerNeurobiology and Genetics, Theodor-Boveri-Institute, Biocentre, Julius-Maximilians-University of Würzburg, Würzburg 97074, Germany.ORCID 0000-0001-5597-5858
Weihua LiDepartment of Neuroscience, Washington University School of Medicine, St. Louis, MO 63105.
Paul H TaghertDepartment of Neuroscience, Washington University School of Medicine, St. Louis, MO 63105.ORCID 0000-0002-5399-2993
Taishi YoshiiGraduate School of Environmental, Life, Natural Science and Technology, Okayama University, Okayama 700-8530, Japan.
Charlotte Helfrich-FörsterNeurobiology and Genetics, Theodor-Boveri-Institute, Biocentre, Julius-Maximilians-University of Würzburg, Würzburg 97074, Germany.ORCID 0000-0002-0859-9092

Funding

MECHANISMS OF CIRCADIAN CLOCK OUTPUTR01NS108393 · NINDS · WASHINGTON UNIVERSITY · PI TAGHERT, PAUL H · 2018 to 2022
$1.6M
Neuropeptide modulation in circadian neural circuitsR01NS140408 · NINDS · WASHINGTON UNIVERSITY · PI Paul H Taghert · 2025 to 2026
$861k
Deutsche Forschungsgemeinschaft (DFG) BE 7089/1-1Deutsche Forschungsgemeinschaft (DFG) FO 207/16-1Deutsche Forschungsgemeinschaft (DFG) RI 2411/1-1HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS) R01NS108393Japan Society for the Promotion of Science London (JSPS) KAKENHI; 24K09534NINDS NIH HHS R01 NS108393NINDS NIH HHS R01 NS140408
6 · The paper itself

Abstract

Circadian clocks form complex networks to orchestrate the behavior and physiology of animals. Elucidating the organization of these clock networks is critical to understanding how circadian clocks achieve robust timing. Clock neurons have been best characterized in the model organism

Indexed as

Circadian ClocksCircadian RhythmDrosophila melanogasterNeuronsAnimalsDrosophila ProteinsSignal TransductionDrosophila Proteinscircadian rhythmdorsal neuronsDrosophilaneuropeptidesperiod

Identifiers

PMID41150714
PMCPMC12595503

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.