ArticleScientific reports2025
Evaluation of the efficacy of combination therapy in the treatment of fungal otitis externa.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Research and Application of the Polyene Macrolide Antibiotic Nystatin.Molecules (Basel, Switzerland) · 2026Review
- Correlation between MIC of econazole nitrate and clinical response in otomycosis.Frontiers in cellular and infection microbiology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Assess the efficacy of sodium bicarbonate solution and Triamcinolone Acetonide and Econazole Nitrate Cream combination therapy in the treatment of fungal otitis externa. The experimental group received a combination therapy consisting of sodium bicarbonate solution and Triamcinolone Acetonide and Econazole Nitrate Cream, while the control group was treated with saline in conjunction with Triamcinolone Acetonide and Econazole Nitrate Cream. The degree of external ear canal cleanliness was evaluated using endoscopic Visual Analog Scale (VAS) scores before and after the intervention. Statistical analysis was performed to assess and compare VAS scores across multiple time points and severity levels, with the objective of determining the efficacy of combining sodium bicarbonate solution with Triamcinolone Acetonide and Econazole Nitrate Cream in the treatment of fungal otitis externa. The experimental group exhibited a higher level of treatment efficacy than the control group did. Notably, significant differences in VAS scores were observed between the two groups on the 4th day (t = 4.391, p < 0.001) and the 7th day (t = 5.754, p < 0.001), indicating consistent superiority of the therapeutic effect in the experimental group. Specifically, at the end of the 7th day of treatment, the experimental group demonstrated significantly better efficacy than the control group in terms of the mild score (t = 5.101, p < 0.001). The use of sodium bicarbonate solution along with Triamcinolone Acetonide and Econazole Nitrate Cream has proven to be highly effective in treating fungal otitis externa. This underscores the importance of expanding the adoption of this therapeutic approach, highlighting its potential for widespread application.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.