Evidence map›Paper›PMID 41152472›Full record

ArticleCommunications biology2025

OSMRβ-mediated signals on resident fibroblasts restore healing in diabetic skin wounds through promoting angiogenesis and granulation tissue formation.

Yuko Ishida, Yumi Kuninaka, Tadasuke Komori, Sadahiro Iwabuchi, Mizuho Nosaka, Akihiko Kimura, Shinichi Hashimoto, Yoshihiro Morikawa, Naofumi Mukaida, Toshikazu Kondo

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In one paragraph

Article in Communications biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yuko IshidaDepartment of Forensic Medicine, Wakayama Medical University, Wakayama, Japan.
Yumi KuninakaDepartment of Forensic Medicine, Wakayama Medical University, Wakayama, Japan.
Tadasuke KomoriDepartment of Anatomy and Neurobiology, Wakayama Medical University, Wakayama, Japan.
Sadahiro IwabuchiDepartment of Molecular Pathophysiology, Institute of Advanced Medicine, Wakayama Medical University, Wakayama, Japan.
Mizuho NosakaDepartment of Forensic Medicine, Wakayama Medical University, Wakayama, Japan.
Akihiko KimuraDepartment of Forensic Medicine, Wakayama Medical University, Wakayama, Japan.
Shinichi HashimotoDepartment of Molecular Pathophysiology, Institute of Advanced Medicine, Wakayama Medical University, Wakayama, Japan.ORCID http://orcid.org/0000-0002-1223-2349
Yoshihiro MorikawaDepartment of Anatomy and Neurobiology, Wakayama Medical University, Wakayama, Japan.
Naofumi MukaidaDepartment of Forensic Medicine, Wakayama Medical University, Wakayama, Japan.
Toshikazu KondoDepartment of Forensic Medicine, Wakayama Medical University, Wakayama, Japan. kondot@wakayama-med.ac.jp.ORCID http://orcid.org/0000-0002-5059-8309

Funding

MEXT | Japan Society for the Promotion of Science (JSPS) 20249040MEXT | Japan Society for the Promotion of Science (JSPS) 20689015Wakayama Medical University Research Grant on Priority Areas
6 · The paper itself

Abstract

Oncostatin M (OSM) has various biological activities through OSM receptor β (OSMRβ) in many conditions such as inflammation and tissue regeneration, but it remains elusive on its precise roles in skin wound healing. Especially, diabetic mice showed impaired wound healing with suppressed expression of OSM and OSMRβ. Here we show the pathophysiological roles of OSM-OSMRβ axis in skin wound healing utilizing wild-type (WT) and Osmrb

Indexed as

Diabetes Mellitus, ExperimentalFibroblastsGranulation TissueNeovascularization, PhysiologicOncostatin M Receptor beta SubunitSkinWound HealingAngiogenesisAnimalsMaleMiceMice, Inbred C57BLMice, KnockoutOncostatin MSignal TransductionTissue Inhibitor of Metalloproteinase-1Oncostatin MOncostatin M Receptor beta SubunitTissue Inhibitor of Metalloproteinase-1

Identifiers

PMID41152472
PMCPMC12569152

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.