Evidence map›Paper›PMID 41152486›Full record

SynthesisPediatric research2026

Apnoea duration and changes in cardiorespiratory and cerebrovascular responses in preterm neonates: a systematic review and meta-analysis.

Yiru Chen, Coen S Zandvoort, Luke Baxter, Odunayo A T Fatunla, Vithushanan Ketheeswaranathan, Ravi Poorun, Zara Small, Fatima Usman, Matthew Henry, Luc Berthouze and 2 more

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Pediatric research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Yiru ChenDepartment of Paediatrics, University of Oxford, Oxford, UK.
Coen S ZandvoortDepartment of Paediatrics, University of Oxford, Oxford, UK.
Luke BaxterDepartment of Paediatrics, University of Oxford, Oxford, UK.
Odunayo A T FatunlaDepartment of Paediatrics, University of Oxford, Oxford, UK.
Vithushanan KetheeswaranathanDepartment of Paediatrics, University of Oxford, Oxford, UK.
Ravi PoorunUniversity of Exeter Medical School, University of Exeter, Exeter, UK.
Zara SmallMedical Sciences Division, University of Oxford, Oxford, UK.
Fatima UsmanDepartment of Paediatrics, University of Oxford, Oxford, UK.
Matthew HenryBodleian Health Care Libraries, University of Oxford, Oxford, UK.
Luc BerthouzeDepartment of Informatics, University of Sussex, Brighton, UK.
Mauricio VillarroelDepartment of Engineering Science, University of Oxford, Oxford, UK.
Caroline HartleyDepartment of Paediatrics, University of Oxford, Oxford, UK. caroline.hartley@paediatrics.ox.ac.uk.ORCID http://orcid.org/0000-0002-7981-0836

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundApnoea is a common respiratory complication in preterm neonates, leading to substantial changes in physiology. We conducted this systematic review and meta-analysis to examine the relationship between apnoea duration and changes in heart rate, oxygen saturation, cerebral oxygenation and cerebral blood volume in preterm neonates, and to identify factors that modulate this relationship.

methodsWe searched Medline, EMBASE, PsycINFO, and Cochrane Central Register of Controlled Trials databases and included primary empirical studies examining the relationship between apnoea or respiratory pause duration and at least one outcome in hospitalised neonates with postmenstrual age (PMA) <37 weeks. Through meta-analyses, we prospectively examined factors that may modulate this relationship, including postmenstrual age, medication use, and apnoea type.

resultsForty-two papers were included, involving a total of 1483 neonates with 2399 study sessions. The decrease in heart rate, oxygen saturation, and cerebral oxygenation were significantly correlated with apnoea duration. PMA significantly modulated the relationship, with younger neonates more likely to exhibit oxygen desaturation from short apnoeas.

conclusionsCardiorespiratory and cerebrovascular responses to apnoea are correlated with apnoea duration, yet wide variability exists in the response. Further research is needed to identify how factors modulate the relationship. IMPACT: Systematic review and meta-analysis of the relationship between apnoea duration and change in heart rate, oxygen saturation, cerebral oxygenation and cerebral blood volume in preterm neonates. Through meta-analysis, we demonstrate that postmenstrual age plays a significant modulating role in the relationship between apnoea duration and change in oxygen saturation, with younger infants more likely to have desaturations. Apnoea can lead to significant cardiorespiratory and cerebrovascular changes; understanding the factors which modulate these relationships are key to facilitating personalised alarm limits.

Indexed as

ApneaCerebrovascular CirculationInfant, PrematureHeart RateHumansInfant, NewbornOxygenOxygen SaturationTime FactorsOxygen

Identifiers

PMID41152486
PMCPMC13433245

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.