Evidence map›Paper›PMID 41152864›Full record

ArticleBMC oral health2025

Evaluation of piezosurgery combined with L-PRF, A-PRF, and photobiomodulation for optimizing MRONJ treatment: an animal study.

Mohammad Reza Jamalpour, Shiva Shahabi, Abbas Shokri, Shokoofeh Jamshidi, Salman Khazaei, Atefeh Hashemi, Mehdi Baghestani

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mohammad Reza JamalpourDepartment of Oral & Maxillofacial Surgery, School of Dentistry, Hamadan University of Medical Sciences, Hamadan, 6517838636, Iran.
Shiva ShahabiDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.
Abbas ShokriDental Implant Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.
Shokoofeh JamshidiDepartment of Oral and Maxillofacial Pathology, School of Dentistry, Hamadan University of Medical Sciences, Hamadan, Iran.
Salman KhazaeiDental Implant Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.
Atefeh HashemiOral and Maxillofacial Pathologist, Private Practice, Tehran, Iran.
Mehdi BaghestaniDepartment of Oral & Maxillofacial Surgery, School of Dentistry, Hamadan University of Medical Sciences, Hamadan, 6517838636, Iran. Erfanpaknahad01@gmail.com.

Funding

Hamadan University of Medical Sciences 9906043614
6 · The paper itself

Abstract

This research evaluates the complementary roles of piezosurgery, photobiomodulation (PBM), leukocyte- and platelet-rich fibrin (L-PRF), and advanced platelet-rich fibrin (A-PRF) in the management of medication-related osteonecrosis of the jaw (MRONJ). First, we induced MRONJ lesions in rats. All rats were inspected for signs of MRONJ eight weeks post-extraction. Forty-nine rats having positive signs of MRONJ were selected and categorized into seven different groups: C (control), PS (piezosurgery), P (piezosurgery + PBM), A (piezosurgery + A-PRF), L (piezosurgery + L-PRF), A + P (piezosurgery + A-PRF + PBM), and L + P (piezosurgery + L-PRF + PBM). Thirty days after the last treatment session, euthanasia was carried out. Additionally, the healing of the lesions was evaluated radiographically, clinically, and histologically. The data were analyzed using STATA software version 14, with a significance level set at 5%. Based on the current research, L-PRF and A-PRF treatments led to significant improvements in radiographical, clinical, and histological parameters compared to the C group (P ˂ 0.05). The PBM, compared to the C group (P ˂ 0.05), decreased the number of empty lacunae and bone and wound exposure dimensions. 6 out of 7 cases showed complete MRONJ resolution in L + P and A + P (P ˂ 0.05). Consequently, no considerable difference between A-PRF and L-PRF treatment groups was observed (P ˃ 0.05). Considering the limitations of this animal study, we concluded that piezosurgery and photobiomodulation alone, unlike PRF, are insufficient for MRONJ treatment. Importantly, the combination of piezosurgery, PBM, and PRF therapy yielded the most promising results in addressing MRONJ. Further clinical investigations are required to confirm these findings.

Indexed as

Bisphosphonate-Associated Osteonecrosis of the JawLow-Level Light TherapyPiezosurgeryPlatelet-Rich FibrinAnimalsCombined Modality TherapyLeukocytesMaleRatsRats, WistarWound HealingLaser therapyMedication-related osteonecrosis of the jawPhotobiomodulation therapyPiezosurgeryPlatelet-Rich fibrin

Identifiers

PMID41152864
PMCPMC12570787

What Socratic holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.