Evidence map›Paper›PMID 41153002›Full record

ReviewStem cell research & therapy2025

Advances in sweat gland organoids: construction, molecular mechanisms, and challenges.

Xiaohan Liu, Yuanli Ye, Jinyi Chen, Yang Tan, Guihong Yang, Lingfei Li, Hong Liu, Yi Liang, Mingxing Lei, Xia Lei

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Stem cell research & therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xiaohan LiuDepartment of Dermatology, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, 400010, China.
Yuanli YeKey Laboratory of Biorheological Science and Technology of Ministry of Education and 111 Project Laboratory of Biomechanics and Tissue Repair, College of Bioengineering, Chongqing University, Chongqing, 400044, China.
Jinyi ChenDepartment of Dermatology, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, 400010, China.
Yang TanDepartment of Dermatology, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, 400010, China.
Guihong YangDepartment of Dermatology, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, 400010, China.
Lingfei LiDepartment of Dermatology, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, 400010, China.
Hong LiuDepartment of Dermatology, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, 400010, China.
Yi LiangDepartment of Dermatology, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, 400010, China. 15683417308@tmmu.edu.cn.
Mingxing LeiKey Laboratory of Biorheological Science and Technology of Ministry of Education and 111 Project Laboratory of Biomechanics and Tissue Repair, College of Bioengineering, Chongqing University, Chongqing, 400044, China. mingxing@cqu.edu.cn.
Xia LeiDepartment of Dermatology, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, 400010, China. dpyyskinlx@tmmu.edu.cn.ORCID http://orcid.org/0000-0002-7169-3487

Funding

National Natural Science Foundation of China 82473540Open Project of Chongqing Engineering Research Center of Organ Intelligent Bio-Manufacturing CQERC-OIBM20241008the Chongqing Talents: Exceptional Young Talents Project cstc2021ycjh-bgzxm0197the Fundamental Research Funds for the Central Universities 2022CDJYGRH-003 and 2023CDJKYJH066the National Key Research and Development Program of China 2023YFC2508200the National Natural Science Foundation of China 82373509Training Program of Talent Innovation Ability in Daping Hospital of Army Medical University ZXZYTSYS06
6 · The paper itself

Abstract

Sweat glands (SGs) play pivotal roles in systemic and skin homeostasis. However, due to the extremely limited regenerative capacity of SGs, burns and traumas often result in irreversible SGs loss. Recent advancements in three-dimensional (3D) cell culture technology and stem cell research have highlighted the potential of organoid technology in regenerative medicine. This review summarizes the molecular regulatory mechanisms underlying SG development and focuses on the latest progress in sweat gland organoid (SGO) construction. By examining various cell sources, including SG stem cells, mesenchymal stem cells (MSCs), and reprogrammed cells, as well as the influence of 3D culture microenvironments on SGO assembly, we highlighted the promising applications of SGOs in post-burn SG regeneration. Despite challenges in cell induction efficiency and functional reconstruction, SGO technology offers a novel therapeutic strategy for restoring SG function in burn patients.

Indexed as

OrganoidsSweat GlandsAnimalsHumansMesenchymal Stem CellsRegenerationRegenerative MedicineOrganoidsSweat gland regenerationTissue engineeringWound healing

Identifiers

PMID41153002
PMCPMC12570758

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.