ArticleDiabetes, obesity & metabolism2026
Adipocyte-specific deletion of the mineralocorticoid receptor improves glucose homeostasis and associates with FGF21-adiponectin signalling in obese male mice.
Article in Diabetes, obesity & metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- FGF4 activates FGFR1 - PI3K/AKT signaling to enhance Clec10a-mediated intracellular myelin debris processing and promote spinal cord repair.Journal of neuroinflammation · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
aimsThe mineralocorticoid receptor (MR) is a ubiquitous nuclear receptor that is increased during obesity. Fibroblast growth factor 21 (FGF-21) is a hepatokine that enhances glucose metabolism by binding and activating fibroblast growth factor receptors in complex with the beta-klotho co-receptor (β-klotho). This study tested the hypothesis that adipocyte MR contributes to the development of glucose intolerance in obesity settings by impairing FGF-21-mediated glucose handling in adipose tissue. MATERIALS AND
methodsAn adipocyte-specific inducible MR knockout (AdipoMR
resultsBody weight and composition were not significantly different before or after MR deletion in mice of either sex. In HFD-fed male AdipoMR
conclusionsDeletion of the adipocyte MR activates the FGF-21/β-klotho/adiponectin axis in obese male mice only. Thus, these data indicate that the dysfunctional FGF-21/β-klotho/adiponectin axis is associated with impaired glucose handling in a sex-specific manner.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.