Evidence map›Paper›PMID 41153449›Full record

ArticleGenes2025

Population Structure and Genetic Diversity of Tibetan Sheep Revealed by Whole-Genome Resequencing: Implications for Conservation and Breeding.

Junxia Zhang, Litan Zhang, Yuxiang Zhang, Yuting Deng, Xiaocheng Wen

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Association ofAnimals : an open access journal from MDPI · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Junxia ZhangCollege of Agriculture and Animal Husbandry, Qinghai University, Xining 810016, China.
Litan ZhangCollege of Agriculture and Animal Husbandry, Qinghai University, Xining 810016, China.
Yuxiang ZhangCollege of Agriculture and Animal Husbandry, Qinghai University, Xining 810016, China.
Yuting DengCollege of Agriculture and Animal Husbandry, Qinghai University, Xining 810016, China.
Xiaocheng WenCollege of Agriculture and Animal Husbandry, Qinghai University, Xining 810016, China.

Funding

Science and Technology Department of Qinghai Province 2024-ZJ-780
6 · The paper itself

Abstract

backgroundTibetan sheep (

resultsUsing whole-genome resequencing of 90 Tibetan sheep (ZY) compared to 90 Hu sheep (HY) and 90 Small Tail Han sheep (XWHY), we identified significantly higher genetic diversity in Tibetan sheep (Pn = 0.6399, PIC = 0.1731). Population structure analyses revealed distinct clustering of Tibetan sheep, with principal components explaining 20.69% (PCA1), 12.26% (PCA2), and 14.18% (PCA3) of genetic variation. Selective sweep analysis identified 713 genomic regions (containing 207 genes) under positive selection, including key hypoxia adaptation genes (

conclusionsOur study provides the most comprehensive genomic characterization of Tibetan sheep to date, revealing both their unique genetic diversity and molecular mechanisms of high-altitude adaptation. The identified candidate genes offer valuable targets for marker-assisted breeding to improve productivity while maintaining adaptive traits, supporting sustainable development of plateau animal husbandry.

Indexed as

Genetic VariationSheep, DomesticAdaptation, PhysiologicalAltitudeAnimalsBreedingGenetics, PopulationGenomePolymorphism, Single NucleotideSelection, GeneticSheepTibetWhole Genome Sequencinggenetic diversitypopulation structureTibetan sheepwhole-genome resequencing

Identifiers

PMID41153449
PMCPMC12562896

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.