miR-21-5p Alleviates Retinal Ischemia-Reperfusion Injury by Inhibiting M1 Polarization of Microglia via Suppression of STAT3 Signaling.

Liangshi Qin, Junle Liao, Cheng Tan, Can Liu, Wenjia Shi, Dan Chen

Abstract read

In one paragraph

Article in Biomedicines, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it

0cells of the map it votes in

3citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

Stem Cell-Derived Extracellular Vesicles Ameliorate the Neuron Mitochondrial Damage Induced by ROS-, LPS-Exposure: In Vitro Model of Neuron, Microglia, and Astrocyte Triple Co-Culture.International journal of molecular sciences · 2026
Article
MSC-EVs attenuate subretinal fibrosis in choroidal neovascularization through miR-21-5p-mediated inhibition of EMT and MMT and suppression of inflammation.Journal of neuroinflammation · 2026
Article
Regulatory mechanisms of deer antler extracellular vesicles in multilevel tissue repair: a state-of-the-art review.Frontiers in pharmacology · 2026
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Liangshi QinDepartment of Human Anatomy and Neurobiology, School of Basic Medical Sciences, Central South University, Changsha 410013, China.

Junle LiaoDepartment of Human Anatomy and Neurobiology, School of Basic Medical Sciences, Central South University, Changsha 410013, China.

Cheng TanDepartment of Human Anatomy and Neurobiology, School of Basic Medical Sciences, Central South University, Changsha 410013, China.

Can LiuDepartment of Human Anatomy and Neurobiology, School of Basic Medical Sciences, Central South University, Changsha 410013, China.

Wenjia ShiDepartment of Human Anatomy and Neurobiology, School of Basic Medical Sciences, Central South University, Changsha 410013, China.

Dan ChenDepartment of Human Anatomy and Neurobiology, School of Basic Medical Sciences, Central South University, Changsha 410013, China.

Funding

Graduate Student School-Enterprise Joint Innovation Program of Central South University, China 2023XQLH016Natural Science Foundation of Hunan Province, China 2025JJ50478

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

acute ocular hypertensionmicrogliamiR-21-5pmiRNAnerve injuryoxygen–glucose deprivationretinaretinal ganglion cellsRetinal ischemia/reperfusionSTAT3

Identifiers

PMID41153739

DOI10.3390/biomedicines13102456

PMCPMC12561658

What Socratic holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.