Evidence mapPaperPMID 41154136Full record

ArticleBrain sciences2025

Rethinking Melatonin Dosing: Safety and Efficacy at Higher-than-Usual Levels in Aged Patients with Sleep Disturbances and Comorbidities.

Stella M Valiensi, Vanesa A Vera, Agustín L Folgueira, Sofía Caporale, Marcela Ponce de León, Isis Pino Fernández, Daniel E Vigo, Daniel P Cardinali

Abstract read
In one paragraph

Article in Brain sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Stella M ValiensiNeurología-Medicina del Sueño, Hospital Italiano de Buenos Aires, Buenos Aires C1199ABB, Argentina.
Vanesa A VeraNeurología-Medicina del Sueño, Hospital Italiano de Buenos Aires, Buenos Aires C1199ABB, Argentina.
Agustín L FolgueiraNeurología-Medicina del Sueño, Hospital Italiano de Buenos Aires, Buenos Aires C1199ABB, Argentina.ORCID 0000-0001-6053-6155
Sofía CaporaleNeurología-Medicina del Sueño, Hospital Italiano de Buenos Aires, Buenos Aires C1199ABB, Argentina.
Marcela Ponce de LeónNeurología-Medicina del Sueño, Hospital Italiano de Buenos Aires, Buenos Aires C1199ABB, Argentina.
Isis Pino FernándezNeurología-Medicina del Sueño, Hospital Italiano de Buenos Aires, Buenos Aires C1199ABB, Argentina.
Daniel E VigoInstitute for Biomedical Research (BIOMED), National Scientific and Technical Research Council and Pontificia Universidad Católica Argentina, Buenos Aires C1107AAZ, Argentina.
Daniel P CardinaliFacultad de Ciencias Médicas, Pontificia Universidad Católica Argentina, Buenos Aires C1107AAZ, Argentina.ORCID 0000-0002-0813-9088

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

arterial hypertensionchronobioticcytoprotectiondiabetes mellitushigh melatonin doseischemic heart diseasesleep

Identifiers

PMID41154136
PMCPMC12564314

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.