ReviewCancers2025
Epigenetic Regulation of Immune Responses in Endocrine-Related Cancers and Its Role in Immunotherapy.
Review in Cancers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Editorial: Advances in targeted therapy and biomarker research for endocrine-related cancers, volume II.Frontiers in endocrinology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Endocrine-related cancers are commonly diagnosed worldwide and are a major cause of cancer-related deaths. While current therapies are effective at earlier stages, they often fail in more advanced or recurring tumors due to the development of primary and secondary resistance. Therefore, new therapeutic approaches are urgently needed. In recent years, new therapeutic avenues, namely immunotherapy and epigenetic modulation, have been successfully explored in multiple cancer types. However, this success has not been observed in endocrine-related cancers. These tumors are considered immunologically cold, characterized by a low immunogenicity, scarce infiltration by immune cells, and highly immunosuppressive environment rendering them resistant to immunotherapy. Recent studies demonstrated the ability of epigenetic agents to simultaneously alter the behavior of tumor and immune cells, giving premise to combination approaches using epigenetic modulation to prime cancer for immunotherapy. This review provides an overview of the immune landscape of endocrine-related cancers and its main epigenetic regulators. We discuss current clinical trials investigating the effect of combination endocrine-related immunotherapy and their challenges to successfully treat endocrine-related cancers.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.