Evidence mapPaperPMID 41154456Full record

ArticleAntioxidants (Basel, Switzerland)2025

Atorvastatin Induces Bioenergetic Impairment and Oxidative Stress Through Reverse Electron Transport.

Francesca Valenti, Luca Pincigher, Nicola Rizzardi, Francesca Orsini, Christian Bergamini, Romana Fato

Abstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Francesca ValentiDepartment of Pharmacy and Biotechnology, FABiT, University of Bologna, Via Irnerio 48, 40126 Bologna, Italy.ORCID 0000-0002-7266-7352
Luca PincigherDepartment of Pharmacy and Biotechnology, FABiT, University of Bologna, Via Irnerio 48, 40126 Bologna, Italy.ORCID 0009-0002-9806-2789
Nicola RizzardiDepartment of Pharmacy and Biotechnology, FABiT, University of Bologna, Via Irnerio 48, 40126 Bologna, Italy.ORCID 0000-0002-9294-7116
Francesca OrsiniIndena SpA, Viale Ortles, 20139 Milan, Italy.
Christian BergaminiDepartment of Pharmacy and Biotechnology, FABiT, University of Bologna, Via Irnerio 48, 40126 Bologna, Italy.ORCID 0000-0003-4387-5117
Romana FatoDepartment of Pharmacy and Biotechnology, FABiT, University of Bologna, Via Irnerio 48, 40126 Bologna, Italy.ORCID 0000-0002-8945-6826

Funding

European Union and Indena S.p.A. (Milano) PNRR - Mission 4 Component 2, Investment 3.3 "(DM 117/2023)European Union and Indena S.p.A. (Milano) PNRR - Mission 4 Component 2, Investment 3.3 (DM 352/2022)
6 · The paper itself

Abstract

Statins are the first-line therapy for managing elevated cholesterol levels that represent a risk of acute cardiovascular events. However, the use of statins is associated with several side effects, likely due to the depletion of Coenzyme Q

Indexed as

Coenzyme Q10mitochondriaRETstatinUbiqsome

Identifiers

PMID41154456
PMCPMC12561091

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.