Evidence mapPaperPMID 41154479Full record

ReviewAntioxidants (Basel, Switzerland)2025

Microalgae-Derived Peptides Targeting Lifestyle-Related Diseases: Discovery, Mechanisms, Structure-Activity Relationships, and Structural Modifications.

Mohammed S Qoms, Sok Kuan Wong, Norsyahida Mohd Fauzi, Khairana Husain, Suzana Makpol, Jen Kit Tan

Abstract readReview
In one paragraph

Review in Antioxidants (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mohammed S QomsDepartment of Biochemistry, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur 56000, Malaysia.
Sok Kuan WongDepartment of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur 56000, Malaysia.ORCID 0000-0003-1184-4551
Norsyahida Mohd FauziCentre for Drug and Herbal Development, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Kuala Lumpur 50300, Malaysia.
Khairana HusainCentre for Drug and Herbal Development, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Kuala Lumpur 50300, Malaysia.ORCID 0000-0002-0333-0334
Suzana MakpolDepartment of Biochemistry, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur 56000, Malaysia.ORCID 0000-0002-5239-6196
Jen Kit TanDepartment of Biochemistry, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur 56000, Malaysia.ORCID 0000-0002-0824-0581

Funding

Universiti Kebangsaan Malaysia DIP-2024-012
6 · The paper itself

Abstract

Microalgae are an emerging source of bioactive peptides with promising therapeutic potential against lifestyle-related diseases such as oxidative stress-related conditions, hypertension, diabetes, and obesity. While numerous studies have investigated the biological activities of microalgae-derived peptides, a comprehensive understanding of their structural features and structure-activity relationships remains limited. This review provides a detailed overview of current strategies used to discover bioactive peptides from microalgae, encompassing both conventional and computational approaches. Particular emphasis is placed on correlating identified peptide sequences with their reported biological activities to provide critical insights into the key structural motifs responsible for activity. Furthermore, recent advances in peptide modification techniques are discussed in the context of enhancing the bioactivity of microalgae-derived peptides. By integrating discovery strategies, structure-activity relationships, and emerging trends in peptide modification, this review highlights the potential of microalgae-derived peptides as next-generation therapeutic agents for managing lifestyle-related diseases and identifies opportunities for future research and clinical translation.

Indexed as

health propertiesmicroalgae-derived bioactive peptidesmode of actionnon-communicable diseasesoxidative-related diseasesstructural features

Identifiers

PMID41154479
PMCPMC12561970

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.