ArticleAntioxidants (Basel, Switzerland)2025
Oxidative Stress and DNA Damage Biomarkers in Heart Failure: A Systematic Review and Meta-Analysis.
Article in Antioxidants (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed.
- From Oxidative Stress to Fibrotic Remodeling: Integrating Redox Biology, Galectin-3, and Imaging Phenotypes in Heart Failure.Antioxidants (Basel, Switzerland) · 2026Review
- Differential Associations of Oxidative Biomarkers with Symptomatic and Systolic Severity in Heart Failure.Medicina (Kaunas, Lithuania) · 2026Article
- Smart Release of the Antioxidant from Chitosan-Hyaluronan Reservoir in Skin Wound Healing.Pharmaceutics · 2026Review
- Serum malondialdehyde predicts mortality in patients with acute heart failure.Redox biology · 2026Article
- Redox Imbalance in the Cardiohepatic Syndrome: The Emerging Role of Oxidative Stress in Cirrhosis-Associated Cardiac Dysfunction.Antioxidants (Basel, Switzerland) · 2026Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOxidative stress is a key driver of heart failure (HF) pathophysiology, promoting myocardial injury, inflammation, and remodeling. Although numerous biomarkers of oxidative stress and DNA damage have been investigated in HF, their clinical relevance remains uncertain. This systematic review and meta-analysis aimed to evaluate alterations in these biomarkers in HF patients compared to healthy controls.
methodsA comprehensive search of PubMed, MEDLINE, the Cochrane Library, and Web of Science was conducted in accordance with PRISMA guidelines. Studies reporting oxidative stress or DNA damage biomarkers in HF patients versus controls were included. Random-effects models were used to calculate ratios of means (ROM) with 95% confidence intervals (CI). Heterogeneity and publication bias were assessed using the I
resultsData from 3015 HF patients and 2704 controls were analyzed. HF patients had significantly higher levels of 8-hydroxy-2'-deoxyguanosine (8-OHdG) (ROM = 2.24, 95% CI: 1.75-2.88), malondialdehyde (MDA) (ROM = 1.87, 95% CI: 1.49-2.36) and isoprostanes (ROM = 2.83, 95% CI: 1.97-4.05). Telomere length was significantly shorter (ROM = 0.66, 95% CI: 0.53-0.81), indicating accelerated cellular aging. Considerable heterogeneity was observed across studies.
conclusionThis meta-analysis supports a robust association between oxidative stress, DNA damage, and HF, highlighting the potential role of these biomarkers in disease monitoring and prognosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.