ReviewBiomolecules2025
The Effects and Mechanisms of Low-Intensity Pulsed Ultrasound on Bone Remodeling: From Laboratory to Clinic.
Review in Biomolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed.
- Emerging engineering strategies in bone organoids: From biomimetic scaffolds to dynamic microenvironmental stimulation.Bioactive materials · 2026Review
- Heat shock protein-mediated remodeling of the bone immune microenvironment: mechanisms and precision therapeutic strategies for osteoporosis.Journal of translational medicine · 2026Review
- Low-intensity pulsed ultrasound regulates the osteogenic-adipogenic differentiation balance of rat adipose-derived stem cells via the PI3K/AKT-SREBF1 signaling axis.Stem cells translational medicine · 2026Article
- Regulation of Mitophagy by Low-Intensity Pulsed Ultrasound Attenuates Endothelial Dysfunction.Metabolites · 2026Article
- From physical modalities to energy-responsive biomaterials: Current strategies and challenges in tendon-to-bone healing.Bioactive materials · 2026Review
- Low-Intensity Pulsed Ultrasound in Peripheral and Central Nerve Repair: Mechanisms and Emerging Therapeutic Strategies.Journal of functional biomaterials · 2026Review
- Harnessing piezoelectricity for bone tissue engineering: recapitulating the electrophysiological microenvironment through smart biomaterials.Frontiers in bioengineering and biotechnology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Decades of research and applications have demonstrated that low-intensity pulsed ultrasound (LIPUS) has a certain therapeutic effect on diseases involving bone remodeling. LIPUS operates in a pulsed-wave mode at low intensity, ensuring efficient transmission of acoustic energy to target tissues, thereby providing non-invasive physical stimulation for therapeutic purposes. Bone remodeling refers to the dynamic renewal process of bone tissue that is jointly completed by multiple cells in the bone metabolic microenvironment. LIPUS influences the basic biological processes of bone remodeling in the skeletal system through mechanical, piezoelectric, and thermal effects on bone tissue, triggering a series of biochemical reactions. This article begins with the discovery of ultrasound and research on bone remodeling, introduces the basic parameters and application devices of LIPUS, and reviews the clinical applications of and basic research on LIPUS in bone remodeling disorders. Focusing on the intersection and integration of biomedical fundamentals and ultrasound science, it analyzes the biological and physical mechanisms of LIPUS in research on and applications of bone remodeling disorders and investigates the basic research questions and clinical transformation application scenarios in this field.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.