Mitochondrial Translation Inhibition Triggers an Rst2-Controlled Transcriptional Reprogramming of Carbon Metabolism in Stationary-Phase Cells of Fission Yeast.

Ying Luo, Shaimaa Hassan, Saniya Raut, Jürg Bähler

Abstract read

In one paragraph

Article in Biomolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ying LuoInstitute of Healthy Ageing, Department of Genetics, Evolution & Environment, University College London, London WC1E 6BT, UK.ORCID 0009-0002-2826-4780

Shaimaa HassanInstitute of Healthy Ageing, Department of Genetics, Evolution & Environment, University College London, London WC1E 6BT, UK.

Saniya RautInstitute of Healthy Ageing, Department of Genetics, Evolution & Environment, University College London, London WC1E 6BT, UK.

Jürg BählerInstitute of Healthy Ageing, Department of Genetics, Evolution & Environment, University College London, London WC1E 6BT, UK.ORCID 0000-0003-4036-1532

Funding

China Scholarship Council 202306860040Wellcome Discovery Award 302608/Z/23/ZWellcome Trust

6 · The paper itself

Abstract

Mitochondria possess their own genome, which encodes subunits of the electron transport chain, rendering mitochondrial protein translation essential for cellular energy metabolism. Mitochondrial dysfunction affects nuclear transcription through the retrograde response. We applied RNA-seq to investigate whether and how the inhibition of mitochondrial translation by chloramphenicol (CAP) affects transcriptome regulation in proliferating or stationary-phase cells of

Indexed as

CarbonMitochondriaProtein BiosynthesisSchizosaccharomycesSchizosaccharomyces pombe ProteinsTranscription FactorsChloramphenicolGene Expression Regulation, FungalTranscription, GeneticTranscriptomeCarbonChloramphenicolSchizosaccharomyces pombe ProteinsTranscription Factorscarbon catabolite repressiongenetic interactionsmitochondrial metabolismretrograde responseRNA-seqScr1S. pombestress responsetranscription factortranscriptome

Identifiers

PMID41154583

DOI10.3390/biom15101354

PMCPMC12564598

What Socratic holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.