Evidence map›Paper›PMID 41155147›Full record

ReviewInternational journal of molecular sciences2025

Recent Advances in the Synthesis and Biological Applications of Prenylated Chalcones.

Mouna Hind Laiche, James W Barlow

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Mouna Hind LaicheDepartment of Chemistry, RCSI University of Medicine and Health Sciences, 123 St. Stephen's Green, D02 YN77 Dublin, Ireland.ORCID 0000-0002-4783-848X
James W BarlowDepartment of Chemistry, RCSI University of Medicine and Health Sciences, 123 St. Stephen's Green, D02 YN77 Dublin, Ireland.ORCID 0000-0002-1663-4580

Funding

Irish Research Council GOIPG/2022/1312
6 · The paper itself

Abstract

Prenylated chalcones, a subclass of chalcones distinguished by the addition of one or more prenyl (3-methylbut-2-enyl) groups, have attracted significant attention due to their promising biological activities. The origins, chemical diversity, and synthetic routes used to prepare naturally occurring and synthetic prenylated chalcones are discussed in this review paper, alongside their diverse pharmacological properties, as reported over the past 10 years (2015-2025), mainly emphasising their strong anti-cancer, anti-inflammatory, anti-bacterial, anti-fungal, anti-parasitic, and anti-malarial effects. We address their structure-activity relationships (SARs) to interrogate how prenylation affects the pharmacological activity of these chalcones.

Indexed as

ChalconesAnimalsAnti-Infective AgentsAnti-Inflammatory AgentsAntimalarialsAntineoplastic AgentsHumansPrenylationStructure-Activity RelationshipAnti-Infective AgentsAnti-Inflammatory AgentsAntimalarialsAntineoplastic AgentsChalconesbiological activitychalconeprenylationsynthesis

Identifiers

PMID41155147
PMCPMC12563941

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.