Evidence map›Paper›PMID 41155166›Full record

ArticleInternational journal of molecular sciences2025

Cold Exposure Induces Swine Brown Adipocytes to Display an Island-like Distribution with Atypical Characteristics.

Zhenhua Guo, Lei Lv, Hong Ma, Liang Wang, Bo Fu, Fang Wang, Shuo Yang, Di Liu, Dongjie Zhang

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zhenhua GuoKey Laboratory of Combining Farming and Animal Husbandry, Institute of Animal Husbandry, Heilongjiang Academy of Agricultural Sciences, Ministry of Agriculture and Rural Affairs, No. 368 Xuefu Road, Harbin 150086, China.ORCID 0000-0003-0592-5988
Lei LvWood Science Research Institute of Heilongjiang Academy of Forestry, No. 134 Haping Road, Harbin 150080, China.
Hong MaKey Laboratory of Combining Farming and Animal Husbandry, Institute of Animal Husbandry, Heilongjiang Academy of Agricultural Sciences, Ministry of Agriculture and Rural Affairs, No. 368 Xuefu Road, Harbin 150086, China.
Liang WangKey Laboratory of Combining Farming and Animal Husbandry, Institute of Animal Husbandry, Heilongjiang Academy of Agricultural Sciences, Ministry of Agriculture and Rural Affairs, No. 368 Xuefu Road, Harbin 150086, China.
Bo FuKey Laboratory of Combining Farming and Animal Husbandry, Institute of Animal Husbandry, Heilongjiang Academy of Agricultural Sciences, Ministry of Agriculture and Rural Affairs, No. 368 Xuefu Road, Harbin 150086, China.
Fang WangKey Laboratory of Combining Farming and Animal Husbandry, Institute of Animal Husbandry, Heilongjiang Academy of Agricultural Sciences, Ministry of Agriculture and Rural Affairs, No. 368 Xuefu Road, Harbin 150086, China.
Shuo YangKey Laboratory of Combining Farming and Animal Husbandry, Institute of Animal Husbandry, Heilongjiang Academy of Agricultural Sciences, Ministry of Agriculture and Rural Affairs, No. 368 Xuefu Road, Harbin 150086, China.ORCID 0000-0001-9512-7730
Di LiuKey Laboratory of Combining Farming and Animal Husbandry, Institute of Animal Husbandry, Heilongjiang Academy of Agricultural Sciences, Ministry of Agriculture and Rural Affairs, No. 368 Xuefu Road, Harbin 150086, China.
Dongjie ZhangKey Laboratory of Combining Farming and Animal Husbandry, Institute of Animal Husbandry, Heilongjiang Academy of Agricultural Sciences, Ministry of Agriculture and Rural Affairs, No. 368 Xuefu Road, Harbin 150086, China.

Funding

National Natural Science Foundation of China 32172696Science and Technology Innovation Project of Heilongjiang Academy of Agriculture Sciences CX23ZD06Strategic Priority Research Program of the National Center of Technology Innovation for Pigs NCTIP-XD/C16
6 · The paper itself

Abstract

The original purpose of this study was to compare human and pig scRNA-seq data to determine why pigs do not have brown adipocytes. However, during the experiment, we identified brown adipocytes in pigs. Therefore, we aimed to confirm that these adipocytes were brown adipocytes via a comparative analysis using typical mouse brown adipose tissue sections. We found that swine brown adipocytes were distributed in an island-like pattern, with three typical characteristics: (1) numerous mitochondria and small lipid droplets, (2) a cellular volume smaller than that of white adipocytes, and (3) expression of specific marker genes (

Indexed as

Adipocytes, BrownCold TemperatureAdipose Tissue, BrownAnimalsMiceMicroRNAsSwineThermogenesisUncoupling Protein 3MicroRNAsUncoupling Protein 3browningfatpigUCP3

Identifiers

PMID41155166
PMCPMC12563708

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.