Evidence map›Paper›PMID 41155178›Full record

ArticleInternational journal of molecular sciences2025

Mitochondrial Integrity and Kynurenine Pathway Enzyme Dynamics in the Hippocampus of Rats with Scopolamine-Induced Cognitive Deficits.

Mariola Herbet, Angelika Tkaczyk-Wlizło, Katarzyna Wicha-Komsta, Bartosz Twarowski, Brygida Ślaska, Tomasz Kocki, Krzysztof Kowal, Iwona Piątkowska-Chmiel

Abstract read
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In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mariola HerbetChair and Department of Toxicology, Faculty of Pharmacy, Medical University of Lublin, Jaczewskiego 8b Street, 20-090 Lublin, Poland.ORCID 0000-0001-8975-8093
Angelika Tkaczyk-WlizłoThe Sub-Department of General and Molecular Genetics, Institute of Biological Bases of Animal Production, University of Life Sciences in Lublin, Akademicka 13 Street, 20-950 Lublin, Poland.
Katarzyna Wicha-KomstaChair and Department of Experimental and Clinical Pharmacology, Faculty of Medicine, Medical University of Lublin, Jaczewskiego 8b Street, 20-090 Lublin, Poland.ORCID 0000-0001-9945-7446
Bartosz TwarowskiChair and Department of Toxicology, Faculty of Pharmacy, Medical University of Lublin, Jaczewskiego 8b Street, 20-090 Lublin, Poland.
Brygida ŚlaskaThe Sub-Department of General and Molecular Genetics, Institute of Biological Bases of Animal Production, University of Life Sciences in Lublin, Akademicka 13 Street, 20-950 Lublin, Poland.ORCID 0000-0003-3933-2400
Tomasz KockiChair and Department of Experimental and Clinical Pharmacology, Faculty of Medicine, Medical University of Lublin, Jaczewskiego 8b Street, 20-090 Lublin, Poland.ORCID 0000-0002-7587-2626
Krzysztof KowalThe Sub-Department of General and Molecular Genetics, Institute of Biological Bases of Animal Production, University of Life Sciences in Lublin, Akademicka 13 Street, 20-950 Lublin, Poland.ORCID 0000-0003-4716-5040
Iwona Piątkowska-ChmielChair and Department of Toxicology, Faculty of Pharmacy, Medical University of Lublin, Jaczewskiego 8b Street, 20-090 Lublin, Poland.ORCID 0000-0003-1829-6981

Funding

Statutory Research Funding of the Medical University of Lublin 36
6 · The paper itself

Abstract

Cognitive impairments, particularly in the context of neurodegenerative diseases, are associated with disruptions in mitochondrial function and key metabolic pathways. This study investigates the impact of short-term scopolamine exposure on mitochondrial DNA (mtDNA) stability and the kynurenine pathway (KP) in the hippocampus, a brain region central to learning and memory. We analyzed the mitochondrial D-loop region for mutations and heteroplasmy levels in hippocampal tissue from rats exposed to scopolamine (1 mg/kg/0.4 mL/cc

Indexed as

Cognitive DysfunctionHippocampusKynurenineMitochondriaScopolamineAnimalsDNA, MitochondrialKynurenine 3-MonooxygenaseMaleRatsRats, WistarReceptors, Aryl HydrocarbonTransaminasesDNA, MitochondrialKynurenineKynurenine 3-Monooxygenasekynurenine-oxoglutarate transaminaseReceptors, Aryl HydrocarbonScopolamineTransaminasescognitive impairmentD-loop regionhippocampusKPmitochondrial DNAneurodegenerationscopolamine

Identifiers

PMID41155178
PMCPMC12563731

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.