Evidence mapPaperPMID 41155239Full record

ArticleInternational journal of molecular sciences2025

Boldo Restores Vascularization and Reduces Skeletal Muscle Inflammation in Symptomatic Mice with Dysferlinopathy.

Walter Vásquez, Felipe Troncoso, Andrea Lira, Carlos Escudero, Juan C Sáez

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Walter VásquezDepartamento de Fisiología, Pontificia Universidad Católica de Chile, Santiago 8331150, Chile.ORCID 0000-0003-4113-8172
Felipe TroncosoLaboratorio de Fisiología Vascular, Departamento de Ciencias, Universidad del Bio-Bio, Chillán 3800708, Chile.
Andrea LiraDepartamento de Morfología, Facultad de Medicina, Universidad Andres Bello, Santiago 8370211, Chile.
Carlos EscuderoLaboratorio de Fisiología Vascular, Departamento de Ciencias, Universidad del Bio-Bio, Chillán 3800708, Chile.ORCID 0000-0001-7688-4621
Juan C SáezInstituto de Neurociencias, Centro Interdisciplinario de Neurociencias de Valparaíso, Universidad de Valparaíso, Valparaíso 2360102, Chile.ORCID 0000-0003-3811-0347

Funding

Agencia Nacional de Investigación y Desarrollo 1231523Agencia Nacional de Investigación y Desarrollo 1240295Agencia Nacional de Investigación y Desarrollo 21211179Agencia Nacional de Investigación y Desarrollo 21241885
6 · The paper itself

Abstract

Dysferlinopathies are progressive muscular dystrophies caused by DYSF mutations, leading to impaired membrane repair, chronic inflammation, lipid accumulation, and muscle degeneration. No approved therapies currently halt the progression of this disease. Here, we evaluated the effects of daily oral administration of pulverized Boldo (

Indexed as

InflammationMuscle, SkeletalMuscular Dystrophies, Limb-GirdlePlant ExtractsAnimalsDisease Models, AnimalDysferlinMaleMiceDysferlinDysf protein, mousePlant Extractsdysferlinopathypeumus boldusskeletal muscle

Identifiers

PMID41155239
PMCPMC12563361

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.