Evidence map›Paper›PMID 41155255›Full record

ReviewInternational journal of molecular sciences2025

Targeting Granulin Haploinsufficiency in Frontotemporal Dementia: From Genetic Mechanisms to Therapeutics.

Eva Bagyinszky, Seong Soo A An

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Eva BagyinszkyGraduate School of Environment Department of Industrial and Environmental Engineering, Gachon University, Seongnam 13120, Republic of Korea.ORCID 0000-0002-0487-8668
Seong Soo A AnDepartment of Bionano Technology, Gachon Medical Research Institute, Gachon University, Seongnam 13120, Republic of Korea.ORCID 0000-0002-8123-6183

Funding

National Research Foundation Korea RS-2021-NR060117National Research Foundation Korea RS-2023-0025139
6 · The paper itself

Abstract

Frontotemporal dementia (FTD) is the second most common early-onset dementia after Alzheimer's disease, characterized by progressive neurodegeneration primarily in the frontal and temporal lobes.

Indexed as

Frontotemporal DementiaHaploinsufficiencyProgranulinsAnimalsGenetic TherapyHumansMutationGRN protein, humanProgranulinsfrontotemporal dementiagranulinhaploinsufficiencymutationprogranulin

Identifiers

PMID41155255
PMCPMC12563883

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.