Evidence map›Paper›PMID 41155322›Full record

Trial reportInternational journal of molecular sciences2025

Vitamin D Supplementation and Testosterone Levels in Breast Cancer Survivors.

Anita Minopoli, Piergiacomo Di Gennaro, Giuseppe Porciello, Elvira Palumbo, Sara Vitale, Maria Grimaldi, Rosa Pica, Luca Falzone, Concetta Montagnese, Renato de Falco and 21 more

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors.

Anita MinopoliLaboratory Medicine Unit, Istituto Nazionale Tumori IRCCS Fondazione Pascale-IRCCS di Napoli, 80131 Naples, Italy.ORCID 0000-0001-5909-0547
Piergiacomo Di GennaroMedical Statistics Unit, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.
Giuseppe PorcielloEpidemiology and Biostatistics Unit, Istituto Nazionale Tumori IRCCS Fondazione Pascale-IRCCS di Napoli, 80131 Naples, Italy.ORCID 0000-0002-8731-2773
Elvira PalumboEpidemiology and Biostatistics Unit, Istituto Nazionale Tumori IRCCS Fondazione Pascale-IRCCS di Napoli, 80131 Naples, Italy.
Sara VitaleEpidemiology and Biostatistics Unit, Istituto Nazionale Tumori IRCCS Fondazione Pascale-IRCCS di Napoli, 80131 Naples, Italy.
Maria GrimaldiEpidemiology and Biostatistics Unit, Istituto Nazionale Tumori IRCCS Fondazione Pascale-IRCCS di Napoli, 80131 Naples, Italy.
Rosa PicaEpidemiology and Biostatistics Unit, Istituto Nazionale Tumori IRCCS Fondazione Pascale-IRCCS di Napoli, 80131 Naples, Italy.
Luca FalzoneDepartment of Biomedical and Biotechnological Sciences, Oncologic, Clinical and General Pathology Section, University of Catania, 95124 Catania, Italy.ORCID 0000-0001-7349-6826
Concetta MontagneseInstitute of Food Science, CNR Italy, 83100 Avellino, Italy.
Renato de FalcoLaboratory Medicine Unit, Istituto Nazionale Tumori IRCCS Fondazione Pascale-IRCCS di Napoli, 80131 Naples, Italy.ORCID 0000-0003-0629-425X
Anna CrispoEpidemiology and Biostatistics Unit, Istituto Nazionale Tumori IRCCS Fondazione Pascale-IRCCS di Napoli, 80131 Naples, Italy.ORCID 0000-0002-8455-3328
Denise GiannascoliDivision of Radiology, Istituto Nazionale Tumori IRCCS Fondazione Pascale-IRCCS di Napoli, 80131 Naples, Italy.
Lucia Di CapuaLaboratory Medicine Unit, Istituto Nazionale Tumori IRCCS Fondazione Pascale-IRCCS di Napoli, 80131 Naples, Italy.
Serena MeolaLaboratory Medicine Unit, Istituto Nazionale Tumori IRCCS Fondazione Pascale-IRCCS di Napoli, 80131 Naples, Italy.
Monica PintoRehabilitation Medicine Unit, Istituto Nazionale Tumori IRCCS Fondazione Pascale-IRCCS di Napoli, 80131 Naples, Italy.ORCID 0000-0002-0823-4907
Michelino De LaurentiisDepartment of Breast and Thoracic Oncology, Istituto Nazionale Tumori IRCCS Fondazione Pascale-IRCCS di Napoli, 80131 Naples, Italy.ORCID 0000-0001-9009-1572
Vincenzo Di LauroDepartment of Breast and Thoracic Oncology, Istituto Nazionale Tumori IRCCS Fondazione Pascale-IRCCS di Napoli, 80131 Naples, Italy.ORCID 0000-0002-2124-7534
Francesco FerraùOspedale San Vincenzo, 98039 Taormina, Italy.
Francesca CatalanoCannizzaro Hospital, 95021 Catania, Italy.
Francesco MessinaOspedale Evangelico Betania, 80147 Naples, Italy.
Massimiliano D'AiutoBreast Unit, Ospedale di Boscotrecase, 80042 Boscotrecase, Italy.ORCID 0000-0002-4188-5226
Massimo RinaldoBreast Unit, Ospedale di Boscotrecase, 80042 Boscotrecase, Italy.
Vincenzo MontesarchioUOC Oncologia, AORN dei Colli (Monaldi-Cotugno-CTO), 80131 Naples, Italy.
Davide GattiRheumatology Unit, University of Verona, 37129 Verona, Italy.ORCID 0000-0002-7471-3076
Agostino SteffanImmunopathology and Cancer Biomarkers Unit, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, 33081 Aviano, Italy.ORCID 0000-0002-6320-3054
Samuele MassarutChirurgia Oncologica del Seno-Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, 33081 Aviano, Italy.
Jerry PoleselUnit of Cancer Epidemiology, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, 33081 Aviano, Italy.ORCID 0000-0001-9381-1520
Massimo LibraDepartment of Biomedical and Biotechnological Sciences, Oncologic, Clinical and General Pathology Section, University of Catania, 95124 Catania, Italy.ORCID 0000-0002-7232-7737
Ernesta CavalcantiLaboratory Medicine Unit, Istituto Nazionale Tumori IRCCS Fondazione Pascale-IRCCS di Napoli, 80131 Naples, Italy.ORCID 0000-0001-6302-1579
Egidio CelentanoEpidemiology and Biostatistics Unit, Istituto Nazionale Tumori IRCCS Fondazione Pascale-IRCCS di Napoli, 80131 Naples, Italy.ORCID 0000-0002-3193-5699
Livia S A AugustinEpidemiology and Biostatistics Unit, Istituto Nazionale Tumori IRCCS Fondazione Pascale-IRCCS di Napoli, 80131 Naples, Italy.ORCID 0000-0002-6673-8281

Funding

5XMILLE_2021_2 and Italian Ministry of Health Finalizzata grant RF-PE-2013-02358099 5XMILLE_2021_2
6 · The paper itself

Abstract

Vitamin D plays a key role in immune modulation, cell proliferation, and hormone regulation. Dysregulated testosterone may contribute to breast cancer progression. We investigated whether long-term vitamin D supplementation affects serum testosterone levels in breast cancer survivors. Complete data at baseline, 12, and 24 months were derived from 253 women with early-stage breast cancer participating in the DEDiCa trial and randomized to receive either a high-dose vitamin D to maintain serum 25(OH)D at 60 ng/mL (group A) or a standard dose to maintain serum levels at 30 ng/mL (group B). Serum 25(OH)D levels significantly increased in both groups (

Indexed as

Breast NeoplasmsCancer SurvivorsDietary SupplementsTestosteroneVitamin DAdultAgedFemaleHumansMiddle Aged25-hydroxyvitamin DTestosteroneVitamin D25-hydroxyvitamin D [25(OH)D]androgensaromatase inhibitorsbody mass index (BMI)breast cancer survivorscholecalciferol (vitamin D)hormone-suppressive therapylifestyle interventionsex hormone–binding globulin (SHBG)testosterone

Identifiers

PMID41155322
PMCPMC12564732

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.